4m5h

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==The Identification, Analysis and Structure-Based Development of Novel Inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase==
==The Identification, Analysis and Structure-Based Development of Novel Inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase==
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<StructureSection load='4m5h' size='340' side='right' caption='[[4m5h]], [[Resolution|resolution]] 1.11&Aring;' scene=''>
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<StructureSection load='4m5h' size='340' side='right'caption='[[4m5h]], [[Resolution|resolution]] 1.11&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4m5h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M5H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M5H FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4m5h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M5H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M5H FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=APC:DIPHOSPHOMETHYLPHOSPHONIC+ACID+ADENOSYL+ESTER'>APC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=YH2:4-{[(2-AMINO-6-OXO-6,9-DIHYDRO-1H-PURIN-8-YL)SULFANYL]METHYL}BENZONITRILE'>YH2</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=APC:DIPHOSPHOMETHYLPHOSPHONIC+ACID+ADENOSYL+ESTER'>APC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=YH2:4-{[(2-AMINO-6-OXO-6,9-DIHYDRO-1H-PURIN-8-YL)SULFANYL]METHYL}BENZONITRILE'>YH2</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1q0n|1q0n]], [[1hka|1hka]], [[1kbr|1kbr]], [[4m5g|4m5g]], [[4m5i|4m5i]], [[4m5j|4m5j]], [[4m5k|4m5k]], [[4m5l|4m5l]], [[4m5m|4m5m]], [[4m5n|4m5n]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m5h OCA], [https://pdbe.org/4m5h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m5h RCSB], [https://www.ebi.ac.uk/pdbsum/4m5h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m5h ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">folK, b0142, JW0138 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2-amino-4-hydroxy-6-hydroxymethyldihydropteridine_diphosphokinase 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.6.3 2.7.6.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m5h OCA], [http://pdbe.org/4m5h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4m5h RCSB], [http://www.ebi.ac.uk/pdbsum/4m5h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4m5h ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HPPK_ECOLI HPPK_ECOLI]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[6-hydroxymethyl-7%2C8-dihydropterin pyrophosphokinase|6-hydroxymethyl-7%2C8-dihydropterin pyrophosphokinase]]
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*[[HPPK 3D structures|HPPK 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase]]
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[[Category: Escherichia coli K-12]]
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[[Category: Ecoli]]
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[[Category: Large Structures]]
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[[Category: Hoagland, D]]
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[[Category: Hoagland D]]
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[[Category: Kumar, G]]
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[[Category: Kumar G]]
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[[Category: Lee, R E]]
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[[Category: Lee RE]]
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[[Category: Rock, C O]]
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[[Category: Rock CO]]
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[[Category: Waddell, B]]
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[[Category: Waddell B]]
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[[Category: White, S W]]
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[[Category: White SW]]
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[[Category: Yun, M]]
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[[Category: Yun M]]
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[[Category: Atp binding]]
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[[Category: Diphosphotransferase]]
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[[Category: Folate biosynthesis]]
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[[Category: Inhibitor]]
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[[Category: Pterin]]
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[[Category: Transferase-transferase inhibitor complex]]
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Revision as of 10:57, 21 December 2022

The Identification, Analysis and Structure-Based Development of Novel Inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase

PDB ID 4m5h

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