4mh0

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<StructureSection load='4mh0' size='340' side='right'caption='[[4mh0]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='4mh0' size='340' side='right'caption='[[4mh0]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4mh0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MH0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MH0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4mh0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MH0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MH0 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HR4:(2S,4AR,6R,7R,7AS)-6-{6-AMINO-8-[(4-FLUOROBENZYL)SULFANYL]-9H-PURIN-9-YL}-2-SULFANYLTETRAHYDRO-4H-FURO[3,2-D][1,3,2]DIOXAPHOSPHININ-7-OL+2-OXIDE'>HR4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HR4:(2S,4AR,6R,7R,7AS)-6-{6-AMINO-8-[(4-FLUOROBENZYL)SULFANYL]-9H-PURIN-9-YL}-2-SULFANYLTETRAHYDRO-4H-FURO[3,2-D][1,3,2]DIOXAPHOSPHININ-7-OL+2-OXIDE'>HR4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2byv|2byv]], [[3cf6|3cf6]], [[4mgi|4mgi]], [[4mgk|4mgk]], [[4mgy|4mgy]], [[4mgz|4mgz]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mh0 OCA], [https://pdbe.org/4mh0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mh0 RCSB], [https://www.ebi.ac.uk/pdbsum/4mh0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mh0 ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rapgef4, Cgef2, Epac2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), RAP1B, OK/SW-cl.11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mh0 OCA], [http://pdbe.org/4mh0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mh0 RCSB], [http://www.ebi.ac.uk/pdbsum/4mh0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mh0 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RPGF4_MOUSE RPGF4_MOUSE]] Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2.<ref>PMID:11056535</ref> [[http://www.uniprot.org/uniprot/RAP1B_HUMAN RAP1B_HUMAN]] GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction.<ref>PMID:20332120</ref> <ref>PMID:18660803</ref>
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[https://www.uniprot.org/uniprot/RPGF4_MOUSE RPGF4_MOUSE] Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2.<ref>PMID:11056535</ref>
==See Also==
==See Also==
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*[[GTP-binding protein|GTP-binding protein]]
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*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Rehmann, H]]
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[[Category: Rehmann H]]
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[[Category: Guanine nucleotide exchange factor]]
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[[Category: Nucleotide binding]]
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[[Category: Signaling protein-gtp-binding protein complex]]
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Revision as of 11:16, 21 December 2022

Selective activation of Epac1 and Epac2

PDB ID 4mh0

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