This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1jh5

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1jh5.gif|left|200px]]
[[Image:1jh5.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1jh5 |SIZE=350|CAPTION= <scene name='initialview01'>1jh5</scene>, resolution 3.00&Aring;
+
The line below this paragraph, containing "STRUCTURE_1jh5", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1jh5| PDB=1jh5 | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jh5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jh5 OCA], [http://www.ebi.ac.uk/pdbsum/1jh5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jh5 RCSB]</span>
+
-
}}
+
'''Crystal Structure of sTALL-1 of TNF family ligand'''
'''Crystal Structure of sTALL-1 of TNF family ligand'''
Line 30: Line 27:
[[Category: Xu, L.]]
[[Category: Xu, L.]]
[[Category: Zhang, G.]]
[[Category: Zhang, G.]]
-
[[Category: baff]]
+
[[Category: Baff]]
-
[[Category: bly]]
+
[[Category: Bly]]
-
[[Category: tall-1]]
+
[[Category: Tall-1]]
-
[[Category: thank]]
+
[[Category: Thank]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:12:53 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:33:36 2008''
+

Revision as of 18:12, 2 May 2008

Image:1jh5.gif

Template:STRUCTURE 1jh5

Crystal Structure of sTALL-1 of TNF family ligand


Overview

TALL-1/BAFF/BLyS was recently identified as a member of the tumor necrosis factor (TNF) ligand family. The crystal structure of the functional soluble TALL-1 (sTALL-1) has been determined at 3.0 A. sTALL-1 forms a virus-like assembly with 200 A diameter in the crystals, containing 60 sTALL-1 monomers. The cluster formation is mediated by a "flap" region of the sTALL-1 monomer. The virus-like assembly was also detected in solution using gel filtration and electron microscopy. Deletion of the flap region disrupted the formation of the virus-like assembly. The mutant sTALL-1 still bound its receptor but could not activate NF-kappaB and did not stimulate B lymphocyte proliferation. Finally, we found the virus-like cluster of sTALL-1 exists in physiological condition. We propose that this virus-like assembly of sTALL-1 is the functional unit for TALL-1 in vivo.

About this Structure

1JH5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands., Liu Y, Xu L, Opalka N, Kappler J, Shu HB, Zhang G, Cell. 2002 Feb 8;108(3):383-94. PMID:11853672 Page seeded by OCA on Fri May 2 21:12:53 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1jh5"
Personal tools