7xw9

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'''Unreleased structure'''
 
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The entry 7xw9 is ON HOLD until Paper Publication
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==Cryo-EM structure of the TRH-bound human TRHR-Gq complex==
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<StructureSection load='7xw9' size='340' side='right'caption='[[7xw9]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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Authors: Ji, S., Dong, Y., Chen, L., Zang, S., Shen, D., Guo, J., Qin, J., Zhang, H., Wang, W., Shen, Q., Mao, C., Zhang, Y.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7xw9]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XW9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XW9 FirstGlance]. <br>
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Description: Cryo-EM structure of the TRH-bound human TRHR-Gq complex
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xw9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xw9 OCA], [https://pdbe.org/7xw9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xw9 RCSB], [https://www.ebi.ac.uk/pdbsum/7xw9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xw9 ProSAT]</span></td></tr>
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[[Category: Zhang, Y]]
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</table>
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[[Category: Zhang, H]]
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== Disease ==
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[[Category: Guo, J]]
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[https://www.uniprot.org/uniprot/TRFR_HUMAN TRFR_HUMAN] Resistance to thyrotropin-releasing hormone syndrome. The disease is caused by variants affecting the gene represented in this entry.
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[[Category: Wang, W]]
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== Function ==
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[[Category: Zang, S]]
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[https://www.uniprot.org/uniprot/TRFR_HUMAN TRFR_HUMAN] Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.<ref>PMID:26735259</ref> <ref>PMID:9141550</ref>
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[[Category: Shen, D]]
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== References ==
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[[Category: Dong, Y]]
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<references/>
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[[Category: Ji, S]]
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__TOC__
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[[Category: Shen, Q]]
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</StructureSection>
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[[Category: Mao, C]]
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[[Category: Bos taurus]]
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[[Category: Chen, L]]
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[[Category: Homo sapiens]]
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[[Category: Qin, J]]
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[[Category: Large Structures]]
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[[Category: Rattus norvegicus]]
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[[Category: Synthetic construct]]
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[[Category: Chen L]]
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[[Category: Dong Y]]
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[[Category: Guo J]]
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[[Category: Ji S]]
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[[Category: Mao C]]
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[[Category: Qin J]]
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[[Category: Shen D]]
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[[Category: Shen Q]]
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[[Category: Wang W]]
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[[Category: Zang S]]
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[[Category: Zhang H]]
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[[Category: Zhang Y]]

Revision as of 08:59, 28 December 2022

Cryo-EM structure of the TRH-bound human TRHR-Gq complex

PDB ID 7xw9

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