7zir
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of hnRNPDL amyloid fibrils== | |
| - | + | <StructureSection load='7zir' size='340' side='right'caption='[[7zir]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7zir]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZIR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZIR FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zir FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zir OCA], [https://pdbe.org/7zir PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zir RCSB], [https://www.ebi.ac.uk/pdbsum/7zir PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zir ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/HNRDL_HUMAN HNRDL_HUMAN] HNRNPDL-related limb-girdle muscular dystrophy D3. The disease is caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HNRDL_HUMAN HNRDL_HUMAN] Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes (By similarity). Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter (By similarity). Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence.<ref>PMID:9538234</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bartolome-Nafria A]] | ||
| + | [[Category: Bolognesi M]] | ||
| + | [[Category: Chaves-Sanjuan A]] | ||
| + | [[Category: Garcia-Pardo J]] | ||
| + | [[Category: Gil-Garcia M]] | ||
| + | [[Category: Ricagno S]] | ||
| + | [[Category: Ventura S]] | ||
| + | [[Category: Visentin C]] | ||
Revision as of 09:00, 28 December 2022
Cryo-EM structure of hnRNPDL amyloid fibrils
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