1jht

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[[Image:1jht.gif|left|200px]]
[[Image:1jht.gif|left|200px]]
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{{Structure
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|PDB= 1jht |SIZE=350|CAPTION= <scene name='initialview01'>1jht</scene>, resolution 2.15&Aring;
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The line below this paragraph, containing "STRUCTURE_1jht", creates the "Structure Box" on the page.
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|SITE=
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{{STRUCTURE_1jht| PDB=1jht | SCENE= }}
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|RELATEDENTRY=[[1jf1|1JF1]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jht OCA], [http://www.ebi.ac.uk/pdbsum/1jht PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jht RCSB]</span>
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'''Crystal structure of HLA-A2*0201 in complex with a nonameric altered peptide ligand (ALGIGILTV) from the MART-1/Melan-A.'''
'''Crystal structure of HLA-A2*0201 in complex with a nonameric altered peptide ligand (ALGIGILTV) from the MART-1/Melan-A.'''
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[[Category: Sliz, P.]]
[[Category: Sliz, P.]]
[[Category: Wiley, D.]]
[[Category: Wiley, D.]]
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[[Category: class i]]
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[[Category: Class i]]
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[[Category: human]]
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[[Category: Human]]
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[[Category: melanoma]]
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[[Category: Melanoma]]
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[[Category: melanoma antigen]]
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[[Category: Melanoma antigen]]
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[[Category: mhc]]
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[[Category: Mhc]]
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[[Category: tumor immunity]]
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[[Category: Tumor immunity]]
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[[Category: vaccination]]
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[[Category: Vaccination]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:14:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:33:51 2008''
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Revision as of 18:14, 2 May 2008

Image:1jht.gif

Template:STRUCTURE 1jht

Crystal structure of HLA-A2*0201 in complex with a nonameric altered peptide ligand (ALGIGILTV) from the MART-1/Melan-A.


Overview

We have determined high-resolution crystal structures of the complexes of HLA-A2 molecules with two modified immunodominant peptides from the melanoma tumor-associated protein Melan-A/Melanoma Ag recognized by T cells-1. The two peptides, a decamer and nonamer with overlapping sequences (ELAGIGILTV and ALGIGILTV), are modified in the second residue to increase their affinity for HLA-A2. The modified decamer is more immunogenic than the natural peptide and a candidate for peptide-based melanoma immunotherapy. The crystal structures at 1.8 and 2.15 A resolution define the differences in binding modes of the modified peptides, including different clusters of water molecules that appear to stabilize the peptide-HLA interaction. The structures suggest both how the wild-type peptides would bind and how three categories of cytotoxic T lymphocytes with differing fine specificity might recognize the two peptides.

About this Structure

1JHT is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structures of two closely related but antigenically distinct HLA-A2/melanocyte-melanoma tumor-antigen peptide complexes., Sliz P, Michielin O, Cerottini JC, Luescher I, Romero P, Karplus M, Wiley DC, J Immunol. 2001 Sep 15;167(6):3276-84. PMID:11544315 Page seeded by OCA on Fri May 2 21:14:19 2008

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