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| | ==Crystal structure of the C2A domain of DOC2A== | | ==Crystal structure of the C2A domain of DOC2A== |
| - | <StructureSection load='4mjj' size='340' side='right' caption='[[4mjj]], [[Resolution|resolution]] 2.00Å' scene=''> | + | <StructureSection load='4mjj' size='340' side='right'caption='[[4mjj]], [[Resolution|resolution]] 2.00Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[4mjj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MJJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MJJ FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4mjj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MJJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MJJ FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DOC2A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mjj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mjj OCA], [https://pdbe.org/4mjj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mjj RCSB], [https://www.ebi.ac.uk/pdbsum/4mjj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mjj ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mjj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mjj OCA], [http://pdbe.org/4mjj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mjj RCSB], [http://www.ebi.ac.uk/pdbsum/4mjj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mjj ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/DOC2A_HUMAN DOC2A_HUMAN]] Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells.<ref>PMID:9736751</ref> <ref>PMID:9804756</ref> <ref>PMID:18354201</ref> | + | [https://www.uniprot.org/uniprot/DOC2A_HUMAN DOC2A_HUMAN] Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells.<ref>PMID:9736751</ref> <ref>PMID:9804756</ref> <ref>PMID:18354201</ref> |
| | == References == | | == References == |
| | <references/> | | <references/> |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Human]] | + | [[Category: Homo sapiens]] |
| - | [[Category: Huang, Q Q]] | + | [[Category: Large Structures]] |
| - | [[Category: C2 domain]] | + | [[Category: Huang QQ]] |
| - | [[Category: Calcium binding protein]]
| + | |
| - | [[Category: Doc2a]]
| + | |
| - | [[Category: Metal binding protein]]
| + | |
| Structural highlights
Function
DOC2A_HUMAN Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells.[1] [2] [3]
References
- ↑ Mochida S, Orita S, Sakaguchi G, Sasaki T, Takai Y. Role of the Doc2 alpha-Munc13-1 interaction in the neurotransmitter release process. Proc Natl Acad Sci U S A. 1998 Sep 15;95(19):11418-22. PMID:9736751
- ↑ Nagano F, Orita S, Sasaki T, Naito A, Sakaguchi G, Maeda M, Watanabe T, Kominami E, Uchiyama Y, Takai Y. Interaction of Doc2 with tctex-1, a light chain of cytoplasmic dynein. Implication in dynein-dependent vesicle transport. J Biol Chem. 1998 Nov 13;273(46):30065-8. PMID:9804756
- ↑ Higashio H, Nishimura N, Ishizaki H, Miyoshi J, Orita S, Sakane A, Sasaki T. Doc2 alpha and Munc13-4 regulate Ca(2+) -dependent secretory lysosome exocytosis in mast cells. J Immunol. 2008 Apr 1;180(7):4774-84. PMID:18354201
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