1ji7

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[[Image:1ji7.gif|left|200px]]
[[Image:1ji7.gif|left|200px]]
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{{Structure
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|PDB= 1ji7 |SIZE=350|CAPTION= <scene name='initialview01'>1ji7</scene>, resolution 1.45&Aring;
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The line below this paragraph, containing "STRUCTURE_1ji7", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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|GENE= TEL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_1ji7| PDB=1ji7 | SCENE= }}
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|RELATEDENTRY=[[1bqv|1BQV]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ji7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ji7 OCA], [http://www.ebi.ac.uk/pdbsum/1ji7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ji7 RCSB]</span>
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'''Crystal Structure of TEL SAM Polymer'''
'''Crystal Structure of TEL SAM Polymer'''
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[[Category: Robinson, M A.]]
[[Category: Robinson, M A.]]
[[Category: Tran, H H.]]
[[Category: Tran, H H.]]
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[[Category: helical polymer]]
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[[Category: Helical polymer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:15:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:34:01 2008''
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Revision as of 18:15, 2 May 2008

Image:1ji7.gif

Template:STRUCTURE 1ji7

Crystal Structure of TEL SAM Polymer


Contents

Overview

TEL is a transcriptional repressor that is a frequent target of chromosomal translocations in a large number of hematalogical malignancies. These rearrangements fuse a potent oligomerization module, the SAM domain of TEL, to a variety of tyrosine kinases or transcriptional regulatory proteins. The self-associating property of TEL-SAM is essential for cell transformation in many, if not all of these diseases. Here we show that the TEL-SAM domain forms a helical, head-to-tail polymeric structure held together by strong intermolecular contacts, providing the first clear demonstration that SAM domains can polymerize. Our results also suggest a mechanism by which SAM domains could mediate the spreading of transcriptional repression complexes along the chromosome.

Disease

Known disease associated with this structure: Leukemia, acute myeloid, somatic OMIM:[600618]

About this Structure

1JI7 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Polymerization of the SAM domain of TEL in leukemogenesis and transcriptional repression., Kim CA, Phillips ML, Kim W, Gingery M, Tran HH, Robinson MA, Faham S, Bowie JU, EMBO J. 2001 Aug 1;20(15):4173-82. PMID:11483520 Page seeded by OCA on Fri May 2 21:15:18 2008

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OCA

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