1i27
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(New page: 200px<br /> <applet load="1i27" size="450" color="white" frame="true" align="right" spinBox="true" caption="1i27, resolution 1.02Å" /> '''CRYSTAL STRUCTURE O...)
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Revision as of 15:19, 12 November 2007
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CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF THE RAP74 SUBUNIT OF HUMAN TRANSCRIPTION FACTOR IIF (TFIIF)
Overview
The x-ray structure of a C-terminal fragment of the RAP74 subunit of human, transcription factor (TF) IIF has been determined at 1.02-A resolution., The alpha/beta structure is strikingly similar to the globular domain of, linker histone H5 and the DNA-binding domain of hepatocyte nuclear factor, 3gamma (HNF-3gamma), making it a winged-helix protein. The surface, electrostatic properties of this compact domain differ significantly from, those of bona fide winged-helix transcription factors (HNF-3gamma and, RFX1) and from the winged-helix domains found within the RAP30 subunit of, TFIIF and the beta subunit of TFIIE. RAP74 has been shown to interact with, the TFIIF-associated C-terminal domain phosphatase FCP1, and a putative, phosphatase binding site has been identified within the RAP74 winged-helix, domain.
About this Structure
1I27 is a Single protein structure of sequence from Homo sapiens with ZN as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of the C-terminal domain of the RAP74 subunit of human transcription factor IIF., Kamada K, De Angelis J, Roeder RG, Burley SK, Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3115-20. PMID:11248041
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