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4mro

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<StructureSection load='4mro' size='340' side='right'caption='[[4mro]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='4mro' size='340' side='right'caption='[[4mro]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4mro]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MRO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MRO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4mro]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MRO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MRO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MG0:2-(4-{4-[(6-AMINOPYRIDIN-3-YL)SULFONYL]PIPERAZIN-1-YL}PHENYL)-1,1,1,3,3,3-HEXAFLUOROPROPAN-2-OL'>MG0</scene>, <scene name='pdbligand=S6P:D-SORBITOL-6-PHOSPHATE'>S6P</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MG0:2-(4-{4-[(6-AMINOPYRIDIN-3-YL)SULFONYL]PIPERAZIN-1-YL}PHENYL)-1,1,1,3,3,3-HEXAFLUOROPROPAN-2-OL'>MG0</scene>, <scene name='pdbligand=S6P:D-SORBITOL-6-PHOSPHATE'>S6P</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4mqu|4mqu]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mro OCA], [https://pdbe.org/4mro PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mro RCSB], [https://www.ebi.ac.uk/pdbsum/4mro PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mro ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GCKR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mro OCA], [http://pdbe.org/4mro PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mro RCSB], [http://www.ebi.ac.uk/pdbsum/4mro PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mro ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GCKR_HUMAN GCKR_HUMAN]] Inhibits glucokinase by forming an inactive complex with this enzyme.
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[https://www.uniprot.org/uniprot/GCKR_HUMAN GCKR_HUMAN] Inhibits glucokinase by forming an inactive complex with this enzyme.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ashton, K S]]
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[[Category: Ashton KS]]
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[[Category: Bartberger, M D]]
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[[Category: Bartberger MD]]
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[[Category: Chen, J]]
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[[Category: Chen J]]
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[[Category: Chmait, S]]
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[[Category: Chmait S]]
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[[Category: Cupples, R]]
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[[Category: Cupples R]]
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[[Category: Fotsch, C]]
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[[Category: Fotsch C]]
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[[Category: Galbreath, E]]
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[[Category: Galbreath E]]
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[[Category: Hale, C]]
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[[Category: Hale C]]
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[[Category: Helmering, J]]
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[[Category: Helmering J]]
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[[Category: Jean, D J.St]]
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[[Category: Jordan SR]]
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[[Category: Jordan, S R]]
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[[Category: Kunz K]]
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[[Category: Kunz, K]]
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[[Category: LLoyd DJ]]
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[[Category: LLoyd, D J]]
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[[Category: Liu L]]
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[[Category: Liu, L]]
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[[Category: Michelsen K]]
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[[Category: Michelsen, K]]
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[[Category: Nishimura N]]
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[[Category: Nishimura, N]]
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[[Category: Norman MH]]
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[[Category: Norman, M H]]
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[[Category: Pennington LD]]
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[[Category: Pennington, L D]]
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[[Category: Poon SF]]
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[[Category: Poon, S F]]
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[[Category: Sivits G]]
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[[Category: Sivits, G]]
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[[Category: St Jean DJ]]
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[[Category: Stec, M M]]
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[[Category: Stec MM]]
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[[Category: Tamayo, N]]
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[[Category: Tamayo N]]
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[[Category: Van, G]]
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[[Category: Van G]]
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[[Category: Yang, K]]
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[[Category: Yang K]]
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[[Category: Glucokinase]]
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[[Category: Phospho-fructose]]
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[[Category: Regulatory protein]]
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[[Category: Sis domain]]
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[[Category: Transferase inhibitor]]
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Revision as of 10:03, 28 December 2022

Human GKRP bound to AMG-5980 and S6P

PDB ID 4mro

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