This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4msu
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Human GKRP bound to AMG-6861 and Sorbitol-6-phosphate== | ==Human GKRP bound to AMG-6861 and Sorbitol-6-phosphate== | ||
| - | <StructureSection load='4msu' size='340' side='right' caption='[[4msu]], [[Resolution|resolution]] 2.50Å' scene=''> | + | <StructureSection load='4msu' size='340' side='right'caption='[[4msu]], [[Resolution|resolution]] 2.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4msu]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4msu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MSU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MSU FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2EU:1,1,1,3,3,3-HEXAFLUORO-2-{4-[4-(THIOPHEN-2-YLSULFONYL)PIPERAZIN-1-YL]PHENYL}PROPAN-2-OL'>2EU</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=S6P:D-SORBITOL-6-PHOSPHATE'>S6P</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2EU:1,1,1,3,3,3-HEXAFLUORO-2-{4-[4-(THIOPHEN-2-YLSULFONYL)PIPERAZIN-1-YL]PHENYL}PROPAN-2-OL'>2EU</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=S6P:D-SORBITOL-6-PHOSPHATE'>S6P</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4msu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4msu OCA], [https://pdbe.org/4msu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4msu RCSB], [https://www.ebi.ac.uk/pdbsum/4msu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4msu ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/GCKR_HUMAN GCKR_HUMAN] Inhibits glucokinase by forming an inactive complex with this enzyme. |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 19: | Line 18: | ||
</div> | </div> | ||
<div class="pdbe-citations 4msu" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4msu" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Glucokinase Regulatory Protein|Glucokinase Regulatory Protein]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Andrews | + | [[Category: Large Structures]] |
| - | [[Category: Ashton | + | [[Category: Andrews KL]] |
| - | [[Category: Bryan | + | [[Category: Ashton KS]] |
| - | [[Category: Chen | + | [[Category: Bryan MC]] |
| - | [[Category: Chen | + | [[Category: Chen J]] |
| - | [[Category: Chen | + | [[Category: Chen K]] |
| - | [[Category: Chmait | + | [[Category: Chen M]] |
| - | [[Category: Croghan | + | [[Category: Chmait S]] |
| - | [[Category: Cupples | + | [[Category: Croghan M]] |
| - | [[Category: Fotsch | + | [[Category: Cupples R]] |
| - | [[Category: Hale | + | [[Category: Fotsch C]] |
| - | [[Category: Helmering | + | [[Category: Hale C]] |
| - | + | [[Category: Helmering J]] | |
| - | [[Category: Jordan | + | [[Category: Jordan SR]] |
| - | [[Category: Kurzeja | + | [[Category: Kurzeja RJ]] |
| - | [[Category: Lloyd | + | [[Category: Lloyd DJ]] |
| - | [[Category: Michelsen | + | [[Category: Michelsen K]] |
| - | [[Category: Pennington | + | [[Category: Pennington LD]] |
| - | [[Category: Poon | + | [[Category: Poon SF]] |
| - | [[Category: Sivits | + | [[Category: Sivits G]] |
| - | [[Category: | + | [[Category: St Jean DJ]] |
| - | [[Category: | + | [[Category: Van G]] |
| - | [[Category: | + | [[Category: Vonderfecht SL]] |
| - | [[Category: | + | [[Category: Wahl RC]] |
| - | [[Category: | + | [[Category: Zhang J]] |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Revision as of 10:06, 28 December 2022
Human GKRP bound to AMG-6861 and Sorbitol-6-phosphate
| |||||||||||
Categories: Homo sapiens | Large Structures | Andrews KL | Ashton KS | Bryan MC | Chen J | Chen K | Chen M | Chmait S | Croghan M | Cupples R | Fotsch C | Hale C | Helmering J | Jordan SR | Kurzeja RJ | Lloyd DJ | Michelsen K | Pennington LD | Poon SF | Sivits G | St Jean DJ | Van G | Vonderfecht SL | Wahl RC | Zhang J
