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| | <StructureSection load='4mt0' size='340' side='right'caption='[[4mt0]], [[Resolution|resolution]] 3.29Å' scene=''> | | <StructureSection load='4mt0' size='340' side='right'caption='[[4mt0]], [[Resolution|resolution]] 3.29Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[4mt0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"diplococcus_gonorrhoeae"_(zopf_1885)_lehmann_and_neumann_1896 "diplococcus gonorrhoeae" (zopf 1885) lehmann and neumann 1896]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MT0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MT0 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4mt0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MT0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MT0 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4msy|4msy]], [[4msz|4msz]], [[4mt1|4mt1]], [[4mt3|4mt3]], [[4mt4|4mt4]]</td></tr>
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mt0 OCA], [https://pdbe.org/4mt0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mt0 RCSB], [https://www.ebi.ac.uk/pdbsum/4mt0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mt0 ProSAT]</span></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mtrE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=485 "Diplococcus gonorrhoeae" (Zopf 1885) Lehmann and Neumann 1896])</td></tr>
| + | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mt0 OCA], [http://pdbe.org/4mt0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mt0 RCSB], [http://www.ebi.ac.uk/pdbsum/4mt0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mt0 ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/Q51006_NEIGO Q51006_NEIGO] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | </StructureSection> | | </StructureSection> |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Bolla, J R]] | + | [[Category: Neisseria gonorrhoeae]] |
| - | [[Category: Su, C C]] | + | [[Category: Bolla JR]] |
| - | [[Category: Yu, E W]] | + | [[Category: Su C-C]] |
| - | [[Category: Beta barrel]] | + | [[Category: Yu EW]] |
| - | [[Category: Membrane protein]]
| + | |
| - | [[Category: Tranport protein]]
| + | |
| Structural highlights
Function
Q51006_NEIGO
Publication Abstract from PubMed
Active efflux of antimicrobial agents is one of the most important strategies used by bacteria to defend against antimicrobial factors present in their environment. Mediating many cases of antibiotic resistance are transmembrane efflux pumps, composed of one or more proteins. The Neisseria gonorrhoeae MtrCDE tripartite multidrug efflux pump, belonging to the hydrophobic and amphiphilic efflux resistance-nodulation-cell division (HAE-RND) family, spans both the inner and outer membranes of N. gonorrhoeae and confers resistance to a variety of antibiotics and toxic compounds. We here describe the crystal structure of N. gonorrhoeae MtrE, the outer membrane component of the MtrCDE tripartite multidrug efflux system. This trimeric MtrE channel forms a vertical tunnel extending down contiguously from the outer membrane surface to the periplasmic end, indicating that our structure of MtrE depicts an open conformational state of this channel.
Crystal structure of the open state of the Neisseria gonorrhoeae MtrE outer membrane channel.,Lei HT, Chou TH, Su CC, Bolla JR, Kumar N, Radhakrishnan A, Long F, Delmar JA, Do SV, Rajashankar KR, Shafer WM, Yu EW PLoS One. 2014 Jun 5;9(6):e97475. doi: 10.1371/journal.pone.0097475. eCollection , 2014. PMID:24901251[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Lei HT, Chou TH, Su CC, Bolla JR, Kumar N, Radhakrishnan A, Long F, Delmar JA, Do SV, Rajashankar KR, Shafer WM, Yu EW. Crystal structure of the open state of the Neisseria gonorrhoeae MtrE outer membrane channel. PLoS One. 2014 Jun 5;9(6):e97475. doi: 10.1371/journal.pone.0097475. eCollection , 2014. PMID:24901251 doi:http://dx.doi.org/10.1371/journal.pone.0097475
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