4mtk

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==Crystal structure of PA0091 VgrG1, the central spike of the Type VI Secretion System==
==Crystal structure of PA0091 VgrG1, the central spike of the Type VI Secretion System==
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<StructureSection load='4mtk' size='340' side='right' caption='[[4mtk]], [[Resolution|resolution]] 3.32&Aring;' scene=''>
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<StructureSection load='4mtk' size='340' side='right'caption='[[4mtk]], [[Resolution|resolution]] 3.32&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4mtk]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MTK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MTK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4mtk]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MTK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MTK FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PA0091, vgrG1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mtk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mtk OCA], [https://pdbe.org/4mtk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mtk RCSB], [https://www.ebi.ac.uk/pdbsum/4mtk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mtk ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mtk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mtk OCA], [http://pdbe.org/4mtk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mtk RCSB], [http://www.ebi.ac.uk/pdbsum/4mtk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mtk ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VGR1A_PSEAE VGR1A_PSEAE] Part of the H1 type VI secretion system (H1-T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection (PubMed:21325275, PubMed:24794869). Forms the spike at the tip of the elongating tube formed by haemolysin co-regulated protein 1/Hcp1 (PubMed:26894531). Allows the delivery of the Tse6 toxin to target cells where it exerts its toxicity (PubMed:30177742).<ref>PMID:21325275</ref> <ref>PMID:24794869</ref> <ref>PMID:26894531</ref> <ref>PMID:30177742</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Pseae]]
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[[Category: Large Structures]]
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[[Category: Leiman, P G]]
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[[Category: Pseudomonas aeruginosa PAO1]]
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[[Category: Shneider, M M]]
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[[Category: Leiman PG]]
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[[Category: Sycheva, L V]]
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[[Category: Shneider MM]]
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[[Category: Beta-barrel]]
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[[Category: Sycheva LV]]
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[[Category: Beta-helix]]
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[[Category: Ob-fold]]
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[[Category: Secreted outside of the cell]]
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[[Category: Toxin]]
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[[Category: Type vi secretion system central spike]]
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Revision as of 10:08, 28 December 2022

Crystal structure of PA0091 VgrG1, the central spike of the Type VI Secretion System

PDB ID 4mtk

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