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4mwi

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==Crystal structure of the human MLKL pseudokinase domain==
==Crystal structure of the human MLKL pseudokinase domain==
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<StructureSection load='4mwi' size='340' side='right' caption='[[4mwi]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='4mwi' size='340' side='right'caption='[[4mwi]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4mwi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MWI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MWI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4mwi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MWI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MWI FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PXN:(2S)-1-[3-{[(2R)-2-HYDROXYPROPYL]OXY}-2,2-BIS({[(2R)-2-HYDROXYPROPYL]OXY}METHYL)PROPOXY]PROPAN-2-OL'>PXN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PXN:(2S)-1-[3-{[(2R)-2-HYDROXYPROPYL]OXY}-2,2-BIS({[(2R)-2-HYDROXYPROPYL]OXY}METHYL)PROPOXY]PROPAN-2-OL'>PXN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4btf|4btf]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mwi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mwi OCA], [https://pdbe.org/4mwi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mwi RCSB], [https://www.ebi.ac.uk/pdbsum/4mwi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mwi ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MLKL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mwi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mwi OCA], [http://pdbe.org/4mwi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mwi RCSB], [http://www.ebi.ac.uk/pdbsum/4mwi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mwi ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MLKL_HUMAN MLKL_HUMAN]] Required for the execution of programmed necrosis.<ref>PMID:22265414</ref>
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[https://www.uniprot.org/uniprot/MLKL_HUMAN MLKL_HUMAN] Required for the execution of programmed necrosis.<ref>PMID:22265414</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Czabotar, P E]]
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[[Category: Large Structures]]
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[[Category: Murphy, J M]]
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[[Category: Czabotar PE]]
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[[Category: Necroptosis]]
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[[Category: Murphy JM]]
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[[Category: Pseudokinase]]
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[[Category: Transferase]]
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Revision as of 10:15, 28 December 2022

Crystal structure of the human MLKL pseudokinase domain

PDB ID 4mwi

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