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4mwo

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<StructureSection load='4mwo' size='340' side='right'caption='[[4mwo]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
<StructureSection load='4mwo' size='340' side='right'caption='[[4mwo]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4mwo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MWO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MWO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4mwo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MWO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MWO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2E2:1-{3,5-O-[(4-CARBOXYPHENYL)(PHOSPHONO)METHYLIDENE]-2-DEOXY-BETA-D-THREO-PENTOFURANOSYL}-5-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE'>2E2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2E2:1-{3,5-O-[(4-CARBOXYPHENYL)(PHOSPHONO)METHYLIDENE]-2-DEOXY-BETA-D-THREO-PENTOFURANOSYL}-5-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE'>2E2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DNT1, DNT2, NT5C, NT5M, UMPH2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4mwo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mwo OCA], [https://pdbe.org/4mwo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4mwo RCSB], [https://www.ebi.ac.uk/pdbsum/4mwo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4mwo ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mwo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mwo OCA], [http://pdbe.org/4mwo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mwo RCSB], [http://www.ebi.ac.uk/pdbsum/4mwo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mwo ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NT5M_HUMAN NT5M_HUMAN]] Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP.
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[https://www.uniprot.org/uniprot/NT5M_HUMAN NT5M_HUMAN] Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Brynda, J]]
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[[Category: Brynda J]]
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[[Category: Pachl, P]]
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[[Category: Pachl P]]
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[[Category: Rezacova, P]]
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[[Category: Rezacova P]]
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[[Category: 5'-nucleotidase]]
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[[Category: Dephosphorylation]]
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[[Category: Had-like]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Mitochondia]]
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[[Category: Phosphorylation]]
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[[Category: Protein conformation]]
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Revision as of 10:15, 28 December 2022

Crystal structure of human mitochondrial 5'(3')-deoxyribonucleotidase in complex with the inhibitor CPB-T

PDB ID 4mwo

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