4my2

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==Crystal Structure of Norrin in fusion with Maltose Binding Protein==
==Crystal Structure of Norrin in fusion with Maltose Binding Protein==
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<StructureSection load='4my2' size='340' side='right' caption='[[4my2]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='4my2' size='340' side='right'caption='[[4my2]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4my2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MY2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MY2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4my2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O157:H7 Escherichia coli O157:H7] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MY2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4MY2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAL:MALTOSE'>MAL</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PRD_900001:alpha-maltose'>PRD_900001</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">malE, Z5632, ECs5017, NDP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4my2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4my2 OCA], [https://pdbe.org/4my2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4my2 RCSB], [https://www.ebi.ac.uk/pdbsum/4my2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4my2 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4my2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4my2 OCA], [http://pdbe.org/4my2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4my2 RCSB], [http://www.ebi.ac.uk/pdbsum/4my2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4my2 ProSAT]</span></td></tr>
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</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/NDP_HUMAN NDP_HUMAN] Retinopathy of prematurity;Familial exudative vitreoretinopathy;Coats disease;Persistent hyperplastic primary vitreous;Norrie disease. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MALE_ECO57 MALE_ECO57]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides (By similarity).
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[https://www.uniprot.org/uniprot/NDP_HUMAN NDP_HUMAN] Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.[https://www.uniprot.org/uniprot/MALE_ECO57 MALE_ECO57] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Escherichia coli O157:H7]]
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[[Category: Chen, C]]
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[[Category: Homo sapiens]]
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[[Category: Gu, X]]
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[[Category: Large Structures]]
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[[Category: Jurecky, C]]
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[[Category: Chen C]]
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[[Category: Ke, J]]
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[[Category: Gu X]]
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[[Category: Melcher, K]]
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[[Category: Jurecky C]]
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[[Category: Parker, N]]
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[[Category: Ke J]]
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[[Category: Williams, B O]]
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[[Category: Melcher K]]
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[[Category: Xu, H E]]
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[[Category: Parker N]]
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[[Category: Angiogenesis]]
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[[Category: Williams BO]]
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[[Category: Cysteine-rich protein]]
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[[Category: Xu HE]]
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[[Category: Cystine-knot growth factor]]
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[[Category: Extracellular]]
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[[Category: Eye development]]
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[[Category: Frizzled 4 receptor]]
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[[Category: Fusion protein]]
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[[Category: Lrp5/6]]
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[[Category: Signaling protein]]
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[[Category: Wnt signaling]]
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[[Category: Wnt/beta-catenin signaling]]
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Revision as of 10:18, 28 December 2022

Crystal Structure of Norrin in fusion with Maltose Binding Protein

PDB ID 4my2

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