4n3n

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==Crystal structure of eukaryotic translation initiation factor eIF5B (517-1116) from Chaetomium thermophilum, apo form==
==Crystal structure of eukaryotic translation initiation factor eIF5B (517-1116) from Chaetomium thermophilum, apo form==
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<StructureSection load='4n3n' size='340' side='right' caption='[[4n3n]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
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<StructureSection load='4n3n' size='340' side='right'caption='[[4n3n]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4n3n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chatd Chatd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N3N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N3N FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4n3n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum_var._thermophilum_DSM_1495 Chaetomium thermophilum var. thermophilum DSM 1495]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N3N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N3N FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LAC:LACTIC+ACID'>LAC</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LAC:LACTIC+ACID'>LAC</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4n3g|4n3g]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n3n OCA], [https://pdbe.org/4n3n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n3n RCSB], [https://www.ebi.ac.uk/pdbsum/4n3n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n3n ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTHT_0029840 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=759272 CHATD])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n3n OCA], [http://pdbe.org/4n3n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4n3n RCSB], [http://www.ebi.ac.uk/pdbsum/4n3n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4n3n ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IF2P_CHATD IF2P_CHATD] Plays a role in translation initiation. Translational GTPase that catalyzes the joining of the 40S and 60S subunits to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. GTP binding and hydrolysis induces conformational changes in the enzyme that renders it active for productive interactions with the ribosome. The release of the enzyme after formation of the initiation complex is a prerequisite to form elongation-competent ribosomes.<ref>PMID:24686316</ref> <ref>PMID:25225612</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Chatd]]
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[[Category: Chaetomium thermophilum var. thermophilum DSM 1495]]
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[[Category: Ficner, R]]
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[[Category: Large Structures]]
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[[Category: Kuhle, B]]
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[[Category: Ficner R]]
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[[Category: Eif5b/if2]]
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[[Category: Kuhle B]]
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[[Category: Gtpase]]
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[[Category: Ribosome]]
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[[Category: Subunit joining]]
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[[Category: Translation]]
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[[Category: Translation initiation]]
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Revision as of 10:30, 28 December 2022

Crystal structure of eukaryotic translation initiation factor eIF5B (517-1116) from Chaetomium thermophilum, apo form

PDB ID 4n3n

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