4n4w

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==Structure of the human smoothened receptor in complex with SANT-1.==
==Structure of the human smoothened receptor in complex with SANT-1.==
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<StructureSection load='4n4w' size='340' side='right' caption='[[4n4w]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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<StructureSection load='4n4w' size='340' side='right'caption='[[4n4w]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4n4w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N4W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4N4W FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4n4w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Shigella_flexneri_5_str._8401 Shigella flexneri 5 str. 8401]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N4W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4N4W FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SNT:(E)-N-(4-BENZYLPIPERAZIN-1-YL)-1-(3,5-DIMETHYL-1-PHENYL-1H-PYRAZOL-4-YL)METHANIMINE'>SNT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=SNT:(E)-N-(4-BENZYLPIPERAZIN-1-YL)-1-(3,5-DIMETHYL-1-PHENYL-1H-PYRAZOL-4-YL)METHANIMINE'>SNT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4jkv|4jkv]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4n4w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n4w OCA], [https://pdbe.org/4n4w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4n4w RCSB], [https://www.ebi.ac.uk/pdbsum/4n4w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4n4w ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SMO, SMOH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n4w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n4w OCA], [http://pdbe.org/4n4w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4n4w RCSB], [http://www.ebi.ac.uk/pdbsum/4n4w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4n4w ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SMO_HUMAN SMO_HUMAN] G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.<ref>PMID:19592253</ref> [https://www.uniprot.org/uniprot/Q0SXH8_SHIF8 Q0SXH8_SHIF8]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Cherezov, V]]
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[[Category: Large Structures]]
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[[Category: GPCR, GPCR Network]]
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[[Category: Shigella flexneri 5 str. 8401]]
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[[Category: Han, G W]]
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[[Category: Cherezov V]]
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[[Category: Stevens, R C]]
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[[Category: Han GW]]
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[[Category: Wang, C]]
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[[Category: Stevens RC]]
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[[Category: Wu, H]]
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[[Category: Wang C]]
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[[Category: Antitumor agent]]
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[[Category: Wu H]]
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[[Category: Gpcr]]
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[[Category: Gpcr network]]
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[[Category: Human smoothened receptor]]
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[[Category: Membrane]]
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[[Category: Membrane protein]]
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[[Category: Novel protein engineering]]
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[[Category: Psi-biology]]
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[[Category: Structural genomic]]
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[[Category: Transport protein]]
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Revision as of 10:35, 28 December 2022

Structure of the human smoothened receptor in complex with SANT-1.

PDB ID 4n4w

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