Polycomb proteins
From Proteopedia
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Polycomb group (PcG) proteins are determinants of gene silencing and epigenetic memory in higher eukaryotes. The PcG system consists of multimeric repressive protein complexes containing chromatin modifying activities which regulate transcription by modulating chromatin structures. The PcG proteins regulate pathways in cell differentiation, tissue regeneration and cancer cell growth<ref>PMID:27705803</ref>. For the '''B'''-cell-specific '''M'''olony leukemia virus '''I'''nsertion site '''1''' (BMI1) see [[BMI1]]. | Polycomb group (PcG) proteins are determinants of gene silencing and epigenetic memory in higher eukaryotes. The PcG system consists of multimeric repressive protein complexes containing chromatin modifying activities which regulate transcription by modulating chromatin structures. The PcG proteins regulate pathways in cell differentiation, tissue regeneration and cancer cell growth<ref>PMID:27705803</ref>. For the '''B'''-cell-specific '''M'''olony leukemia virus '''I'''nsertion site '''1''' (BMI1) see [[BMI1]]. | ||
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| + | See also: [[Polycomb complex protein]]. | ||
== Disease == | == Disease == | ||
Revision as of 08:31, 9 January 2023
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3D structures of polycomb proteins
Updated on 09-January-2023
References
- ↑ Hauri S, Comoglio F, Seimiya M, Gerstung M, Glatter T, Hansen K, Aebersold R, Paro R, Gstaiger M, Beisel C. A High-Density Map for Navigating the Human Polycomb Complexome. Cell Rep. 2016 Oct 4;17(2):583-595. doi: 10.1016/j.celrep.2016.08.096. PMID:27705803 doi:http://dx.doi.org/10.1016/j.celrep.2016.08.096
- ↑ Poynter ST, Kadoch C. Polycomb and trithorax opposition in development and disease. Wiley Interdiscip Rev Dev Biol. 2016 Nov;5(6):659-688. doi: 10.1002/wdev.244., Epub 2016 Sep 1. PMID:27581385 doi:http://dx.doi.org/10.1002/wdev.244
