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Polycomb proteins

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== Structural highlights ==
== Structural highlights ==
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</StructureSection>
</StructureSection>
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==3D structures of polycomb complex proteins==
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==3D structures of polycomb proteins==
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[[Polycomb complex protein 3D structures]]
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[[Polycomb complex proteins 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Polycomb BMI1
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**[[5fr6]] - hPcG - human<br />
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**[[3rpg]] - hPcG + RING1B + Ubch5C<br />
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**[[4r8p]] - hPcG + RING1B + Ubch5C + histones + DNA<br />
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*Polycomb EED
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**[[5wf7]], [[5bjs]], [[5vk3]] - CtPcG + EZH2/PcG SUZ12 - ''Chaetomium thermophilum''<br />
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**[[5wfd]] - CtPcG + zinc finger containing protein + inhibitor<br />
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**[[5wfc]] - CtPcG (mutant) + EZH2/PcG SUZ12 + histone peptide + inhibitor<br />
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**[[5tqr]] - CtPcGCP + EZH2/PCP SUZ12 + SAM<br />
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**[[3jzn]] - hPcG <br />
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**[[5wg6]] - hPcG + EZH2 <br />
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**[[5ij7]], [[5ij8]], [[4w2r]], [[6b3w]] - hPcG + EZH2 + PcG SUZ12 + inhibitor<br />
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**[[5ij8]] - hPcG + EZH2 + PcG SUZ12 + inhibitor<br />
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**[[5ls6]] - hPcG + EZH2 + PcG SUZ12 + Jarid2 K116me3 <br />
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**[[5hyn]] - hPcG + EZH2 + PcG SUZ12 + Jarid2 K116me3 + histone peptide<br />
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**[[6c23]], [[6c24]] - hPcG + EZH2 + PcG SUZ12 + Jarid2 substrate + Jumonji + SUZ12 + RBBP4 - Cryo EM<br />
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**[[4x3e]] - hPcG + Jarid2 peptide <br />
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**[[3jpx]], [[3iiw]], [[3iiy]], [[3ij0]], [[3ij1]], [[3jzg]], [[3jzh]], [[3k26]],[[5fr6]] - hPcG <br />
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**[[5u69]], [[5u6d]], [[5u8a]], [[5k0m]], [[5h13]], [[5u5h]], [[5u5k]], [[5u8f]] - hPcG + inhibitor <br />
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**[[3ijc]] - hPcG (mutant) + inhibitor <br />
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**[[5wp3]] - hPcG + EB22 <br />
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**[[5ttw]] - hPcG + UNC4859 <br />
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**[[5h14]], [[5h15]], [[5h17]], [[5h19]], [[5u5t]], [[5u62]], [[5h25]], [[5gsa]], [[5h24]], [[5wuk]] - hPcG + EZH2 + inhibitor <br />
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**[[1pdq]], [[1pfb]] - DmPcG chromodomain + histone peptide - ''Drosophila melanogaster''<br />
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*Polycomb SUZ12
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**[[5wak]] - hPcG + RBBP4 <br />
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**[[5wai]] - hPcG + RBBP4 + Jarid2 + AEPB2 <br />
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**[[2yb8]] - DmPcG + CAF1<br />
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*Polycomb SCMH1
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**[[2p0k]] - hPcG <br />
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*Polycomb SFMBT
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**[[4c5e]], [[4c5g]], [[4c5h]] - DmPcG + PcG PHO <br />
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**[[5j8y]] - DmPcG + PcG SCM <br />
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**[[3h6z]] - DmPcG + histone peptide <br />
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*Polycomb PCL
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**[[2xk0]] - DmPcG tudor domain - NMR <br />
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**[[5oqd]] - DmPcG Phd2 and winged-helix domain <br />
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*Polycomb SCM
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**[[2r57]] - DmPcG (mutant) <br />
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**[[2r58]], [[2r5a]] - DmPcG (mutant) + methyl-lysine<br />
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**[[2r5m]] - DmPcG (mutant) + peptide <br />
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}}
 
== References ==
== References ==

Revision as of 08:44, 9 January 2023

Human polycomb complex protein BMI-1 (olive and dark red) complex with histones (grey, green, yellow, pink, magenta, cyan, gold, red), RING1B/Ubch5C (aqua and orchid)and DNA (blue and gold) PDB code 4r8p

Drag the structure with the mouse to rotate

3D structures of polycomb proteins

Polycomb complex protein 3D structures


References

  1. ↑ Hauri S, Comoglio F, Seimiya M, Gerstung M, Glatter T, Hansen K, Aebersold R, Paro R, Gstaiger M, Beisel C. A High-Density Map for Navigating the Human Polycomb Complexome. Cell Rep. 2016 Oct 4;17(2):583-595. doi: 10.1016/j.celrep.2016.08.096. PMID:27705803 doi:http://dx.doi.org/10.1016/j.celrep.2016.08.096
  2. ↑ Poynter ST, Kadoch C. Polycomb and trithorax opposition in development and disease. Wiley Interdiscip Rev Dev Biol. 2016 Nov;5(6):659-688. doi: 10.1002/wdev.244., Epub 2016 Sep 1. PMID:27581385 doi:http://dx.doi.org/10.1002/wdev.244

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Jaime Prilusky

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