1jjv

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[[Image:1jjv.gif|left|200px]]
[[Image:1jjv.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1jjv |SIZE=350|CAPTION= <scene name='initialview01'>1jjv</scene>, resolution 2.&Aring;
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The line below this paragraph, containing "STRUCTURE_1jjv", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ATP:ADENOSINE-5&#39;-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Dephospho-CoA_kinase Dephospho-CoA kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.24 2.7.1.24] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= YacE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 Haemophilus influenzae])
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-->
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|DOMAIN=
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{{STRUCTURE_1jjv| PDB=1jjv | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jjv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jjv OCA], [http://www.ebi.ac.uk/pdbsum/1jjv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jjv RCSB]</span>
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}}
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'''DEPHOSPHO-COA KINASE IN COMPLEX WITH ATP'''
'''DEPHOSPHO-COA KINASE IN COMPLEX WITH ATP'''
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[[Category: S2F, Structure 2.Function Project.]]
[[Category: S2F, Structure 2.Function Project.]]
[[Category: Teplyakov, A.]]
[[Category: Teplyakov, A.]]
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[[Category: p-loop nucleotide-binding fold]]
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[[Category: P-loop nucleotide-binding fold]]
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[[Category: s2f]]
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[[Category: S2f]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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[[Category: structure 2 function project]]
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[[Category: Structure 2 function project]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:18:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:34:43 2008''
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Revision as of 18:18, 2 May 2008

Image:1jjv.gif

Template:STRUCTURE 1jjv

DEPHOSPHO-COA KINASE IN COMPLEX WITH ATP


Overview

Dephospho-coenzyme A kinase catalyzes the final step in CoA biosynthesis, the phosphorylation of the 3'-hydroxyl group of ribose using ATP as a phosphate donor. The protein from Haemophilus influenzae was cloned and expressed, and its crystal structure was determined at 2.0-A resolution in complex with ATP. The protein molecule consists of three domains: the canonical nucleotide-binding domain with a five-stranded parallel beta-sheet, the substrate-binding alpha-helical domain, and the lid domain formed by a pair of alpha-helices. The overall topology of the protein resembles the structures of nucleotide kinases. ATP binds in the P-loop in a manner observed in other kinases. The CoA-binding site is located at the interface of all three domains. The double-pocket structure of the substrate-binding site is unusual for nucleotide kinases. Amino acid residues implicated in substrate binding and catalysis have been identified. The structure analysis suggests large domain movements during the catalytic cycle.

About this Structure

1JJV is a Single protein structure of sequence from Haemophilus influenzae. Full crystallographic information is available from OCA.

Reference

Crystal structure of dephospho-coenzyme A kinase from Haemophilus influenzae., Obmolova G, Teplyakov A, Bonander N, Eisenstein E, Howard AJ, Gilliland GL, J Struct Biol. 2001 Nov;136(2):119-25. PMID:11886213 Page seeded by OCA on Fri May 2 21:18:41 2008

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