7rav

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'''Unreleased structure'''
 
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The entry 7rav is ON HOLD until Paper Publication
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==Cryo-EM structure of the unliganded form of NLR family apoptosis inhibitory protein 5 (NAIP5)==
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<StructureSection load='7rav' size='340' side='right'caption='[[7rav]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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Authors: Paidimuddala, B., Cao, J., Xie, Q., Wu, H., Zhang, L.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7rav]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RAV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RAV FirstGlance]. <br>
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Description: Cryo-EM structure of the unliganded form of NLR family apoptosis inhibitory protein 5 (NAIP5)
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rav OCA], [https://pdbe.org/7rav PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rav RCSB], [https://www.ebi.ac.uk/pdbsum/7rav PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rav ProSAT]</span></td></tr>
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[[Category: Zhang, L]]
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</table>
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[[Category: Paidimuddala, B]]
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== Function ==
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[[Category: Wu, H]]
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[https://www.uniprot.org/uniprot/BIR1E_MOUSE BIR1E_MOUSE] Sensor component of the NLRC4 inflammasome that specifically recognizes and binds flagellin from pathogenic bacteria such as Legionella or Salmonella. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria. The NLRC4 inflammasome senses Gram-negative bacteria such as L.pneumophila and P.aeruginosa, enteric pathogens S.typhimurium (Salmonella) and S.flexneri. Prevents motor-neuron apoptosis induced by a variety of signals.<ref>PMID:21874021</ref> <ref>PMID:21918512</ref>
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[[Category: Cao, J]]
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== References ==
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[[Category: Xie, Q]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Cao J]]
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[[Category: Paidimuddala B]]
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[[Category: Wu H]]
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[[Category: Xie Q]]
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[[Category: Zhang L]]

Revision as of 07:31, 11 January 2023

Cryo-EM structure of the unliganded form of NLR family apoptosis inhibitory protein 5 (NAIP5)

PDB ID 7rav

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