8abl
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Complex III2 from Yarrowia lipolytica, with decylubiquinol and antimycin A, consensus refinement== | |
| - | + | <StructureSection load='8abl' size='340' side='right'caption='[[8abl]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8abl]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Yarrowia_lipolytica Yarrowia lipolytica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8ABL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8ABL FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AWB:[(2R,3S,6S,7R,8R)-3-[(3-FORMAMIDO-2-OXIDANYL-PHENYL)CARBONYLAMINO]-8-HEXYL-2,6-DIMETHYL-4,9-BIS(OXIDANYLIDENE)-1,5-DIOXONAN-7-YL]+3-METHYLBUTANOATE'>AWB</scene>, <scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene>, <scene name='pdbligand=PTY:PHOSPHATIDYLETHANOLAMINE'>PTY</scene>, <scene name='pdbligand=XP4:1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHATE'>XP4</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8abl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8abl OCA], [https://pdbe.org/8abl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8abl RCSB], [https://www.ebi.ac.uk/pdbsum/8abl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8abl ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/QCR7_YARLI QCR7_YARLI] Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.[UniProtKB:P00128] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Yarrowia lipolytica]] | ||
| + | [[Category: Kuehlbrandt W]] | ||
| + | [[Category: Wieferig J]] | ||
Revision as of 07:38, 11 January 2023
Complex III2 from Yarrowia lipolytica, with decylubiquinol and antimycin A, consensus refinement
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