1jk9

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[[Image:1jk9.jpg|left|200px]]
[[Image:1jk9.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1jk9 |SIZE=350|CAPTION= <scene name='initialview01'>1jk9</scene>, resolution 2.9&Aring;
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The line below this paragraph, containing "STRUCTURE_1jk9", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1jk9| PDB=1jk9 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jk9 OCA], [http://www.ebi.ac.uk/pdbsum/1jk9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jk9 RCSB]</span>
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}}
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'''Heterodimer between H48F-ySOD1 and yCCS'''
'''Heterodimer between H48F-ySOD1 and yCCS'''
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[[Category: Rosenzweig, A C.]]
[[Category: Rosenzweig, A C.]]
[[Category: Torres, A S.]]
[[Category: Torres, A S.]]
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[[Category: amyotrophic lateral sclerosis]]
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[[Category: Amyotrophic lateral sclerosis]]
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[[Category: chaperone]]
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[[Category: Chaperone]]
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[[Category: copper]]
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[[Category: Copper]]
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[[Category: heterodimer]]
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[[Category: Heterodimer]]
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[[Category: lou gehrig's disease]]
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[[Category: Lou gehrig's disease]]
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[[Category: metallochaperone]]
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[[Category: Metallochaperone]]
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[[Category: protein-protein complex]]
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[[Category: Protein-protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:19:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:34:53 2008''
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Revision as of 18:19, 2 May 2008

Image:1jk9.jpg

Template:STRUCTURE 1jk9

Heterodimer between H48F-ySOD1 and yCCS


Overview

The copper chaperone for superoxide dismutase (CCS) activates the eukaryotic antioxidant enzyme copper, zinc superoxide dismutase (SOD1). The 2.9 A resolution structure of yeast SOD1 complexed with yeast CCS (yCCS) reveals that SOD1 interacts with its metallochaperone to form a complex comprising one monomer of each protein. The heterodimer interface is remarkably similar to the SOD1 and yCCS homodimer interfaces. Striking conformational rearrangements are observed in both the chaperone and target enzyme upon complex formation, and the functionally essential C-terminal domain of yCCS is well positioned to play a key role in the metal ion transfer mechanism. This domain is linked to SOD1 by an intermolecular disulfide bond that may facilitate or regulate copper delivery.

About this Structure

1JK9 is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Heterodimeric structure of superoxide dismutase in complex with its metallochaperone., Lamb AL, Torres AS, O'Halloran TV, Rosenzweig AC, Nat Struct Biol. 2001 Sep;8(9):751-5. PMID:11524675 Page seeded by OCA on Fri May 2 21:19:29 2008

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