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3plc
From Proteopedia
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== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/3SDC7_OPHHA 3SDC7_OPHHA] Acts as a beta-blocker by binding to beta-1 and beta-2 adrenergic receptors (ADRB1 and ADRB2). It dose-dependently decreases the heart rate (bradycardia), whereas conventional cardiotoxins increases it. At 100 mg/kg, intraperitoneal injection into mice provokes labored breathing, impaired locomotion, lack of response to external stimuli, and death (after 30 min).<ref>PMID:17616557</ref> | |
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== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Ophiophagus hannah]] | [[Category: Ophiophagus hannah]] | ||
| - | [[Category: Kini | + | [[Category: Kini RM]] |
| - | [[Category: Qingxiang | + | [[Category: Qingxiang S]] |
| - | [[Category: Roy | + | [[Category: Roy A]] |
| - | [[Category: Sivaraman | + | [[Category: Sivaraman J]] |
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Revision as of 08:08, 11 January 2023
Crystal structure of Beta-Cardiotoxin, a novel three-finger cardiotoxin from the venom of Ophiophagus hannah
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