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4nb6

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==Crystal structure of the ligand binding domain of RORC with T0901317==
==Crystal structure of the ligand binding domain of RORC with T0901317==
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<StructureSection load='4nb6' size='340' side='right' caption='[[4nb6]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
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<StructureSection load='4nb6' size='340' side='right'caption='[[4nb6]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4nb6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NB6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NB6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4nb6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NB6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NB6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=444:N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE'>444</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=444:N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE'>444</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1pqc|1pqc]], [[1pq9|1pq9]], [[2o91|2o91]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nb6 OCA], [https://pdbe.org/4nb6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nb6 RCSB], [https://www.ebi.ac.uk/pdbsum/4nb6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nb6 ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NR1F3, RORC, RORG, RZRG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nb6 OCA], [http://pdbe.org/4nb6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nb6 RCSB], [http://www.ebi.ac.uk/pdbsum/4nb6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nb6 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN]] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
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[https://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Hymowitz, S G]]
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[[Category: Large Structures]]
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[[Category: Leon, G Boenig-de]]
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[[Category: Boenig-de Leon G]]
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[[Category: Alpha-helical]]
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[[Category: Hymowitz SG]]
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[[Category: Nucleus]]
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[[Category: Transcription]]
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[[Category: Transcription factor]]
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Revision as of 08:19, 11 January 2023

Crystal structure of the ligand binding domain of RORC with T0901317

PDB ID 4nb6

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