1jlh

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[[Image:1jlh.gif|left|200px]]
[[Image:1jlh.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1jlh |SIZE=350|CAPTION= <scene name='initialview01'>1jlh</scene>, resolution 2.10&Aring;
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The line below this paragraph, containing "STRUCTURE_1jlh", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucose-6-phosphate_isomerase Glucose-6-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.9 5.3.1.9] </span>
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{{STRUCTURE_1jlh| PDB=1jlh | SCENE= }}
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|RELATEDENTRY=[[1dqr|1dqr]], [[1g98|1g98]], [[1hox|1hox]], [[1iat|1iat]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jlh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jlh OCA], [http://www.ebi.ac.uk/pdbsum/1jlh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jlh RCSB]</span>
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}}
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'''Human Glucose-6-phosphate Isomerase'''
'''Human Glucose-6-phosphate Isomerase'''
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Cordeiro, A T.]]
[[Category: Cordeiro, A T.]]
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[[Category: glycolysis]]
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[[Category: Glycolysis]]
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[[Category: glyconeogenesis]]
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[[Category: Glyconeogenesis]]
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[[Category: isomerase]]
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[[Category: Isomerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:22:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:35:23 2008''
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Revision as of 18:22, 2 May 2008

Image:1jlh.gif

Template:STRUCTURE 1jlh

Human Glucose-6-phosphate Isomerase


Overview

The second enzyme in the glycolytic pathway, phosphoglucose isomerase (PGI), catalyses an intracellular aldose-ketose isomerization. Here we describe the human recombinant PGI structure (hPGI) solved in the absence of active site ligands. Crystals isomorphous to those previously reported were used to collect a 94% complete data set to a limiting resolution of 2.1 A. From the comparison between the free active site hPGI structure and the available human and rabbit PGI (rPGI) structures, a mechanism for protein initial catalytic steps is proposed. Binding of the phosphate moiety of the substrate to two distinct elements of the active site is responsible for driving a series of structural changes resulting in the polarisation of the active site histidine, priming it for the initial ring-opening step of catalysis.

About this Structure

1JLH is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human phosphoglucose isomerase and analysis of the initial catalytic steps., Cordeiro AT, Godoi PH, Silva CH, Garratt RC, Oliva G, Thiemann OH, Biochim Biophys Acta. 2003 Feb 21;1645(2):117-22. PMID:12573240 Page seeded by OCA on Fri May 2 21:22:11 2008

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