4npm

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==Crystal structure of Zebrafish ALKBH5 in complex with succinic acid==
==Crystal structure of Zebrafish ALKBH5 in complex with succinic acid==
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<StructureSection load='4npm' size='340' side='right' caption='[[4npm]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='4npm' size='340' side='right'caption='[[4npm]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4npm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NPM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NPM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4npm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NPM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NPM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4npl|4npl]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4npm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4npm OCA], [https://pdbe.org/4npm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4npm RCSB], [https://www.ebi.ac.uk/pdbsum/4npm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4npm ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">alkbh5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4npm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4npm OCA], [http://pdbe.org/4npm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4npm RCSB], [http://www.ebi.ac.uk/pdbsum/4npm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4npm ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ALKB5_DANRE ALKB5_DANRE]] Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m(6)A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Requires molecular oxygen, alpha-ketoglutarate and iron (By similarity).
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[https://www.uniprot.org/uniprot/ALKB5_DANRE ALKB5_DANRE] Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m(6)A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Requires molecular oxygen, alpha-ketoglutarate and iron (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Dioxygenase|Dioxygenase]]
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*[[Dioxygenase 3D structures|Dioxygenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Brachidanio rerio]]
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[[Category: Danio rerio]]
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[[Category: Chen, W]]
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[[Category: Large Structures]]
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[[Category: He, C]]
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[[Category: Chen W]]
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[[Category: Zhang, L]]
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[[Category: He C]]
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[[Category: Oxidoreductase]]
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[[Category: Zhang L]]

Revision as of 08:40, 11 January 2023

Crystal structure of Zebrafish ALKBH5 in complex with succinic acid

PDB ID 4npm

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