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4npv
From Proteopedia
(Difference between revisions)
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<StructureSection load='4npv' size='340' side='right'caption='[[4npv]], [[Resolution|resolution]] 2.40Å' scene=''> | <StructureSection load='4npv' size='340' side='right'caption='[[4npv]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4npv]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4npv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NPV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NPV FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0NK:6,7,8-TRIMETHOXY-N-(PENTAN-3-YL)QUINAZOLIN-4-AMINE'>0NK</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0NK:6,7,8-TRIMETHOXY-N-(PENTAN-3-YL)QUINAZOLIN-4-AMINE'>0NK</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4npv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4npv OCA], [https://pdbe.org/4npv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4npv RCSB], [https://www.ebi.ac.uk/pdbsum/4npv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4npv ProSAT]</span></td></tr> | |
| - | + | ||
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/PDE1B_HUMAN PDE1B_HUMAN] Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate. |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | + | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Evdomikov | + | [[Category: Evdomikov A]] |
| - | [[Category: Mansour | + | [[Category: Mansour M]] |
| - | [[Category: Pandit | + | [[Category: Pandit J]] |
| - | [[Category: Simons | + | [[Category: Simons S]] |
| - | + | ||
| - | + | ||
Revision as of 08:41, 11 January 2023
Crystal structure of human PDE1B bound to inhibitor 7A (6,7,8-trimethoxy-N-(pentan-3-yl)quinazolin-4-amine)
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