1jm4

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1jm4.gif|left|200px]]
[[Image:1jm4.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1jm4 |SIZE=350|CAPTION= <scene name='initialview01'>1jm4</scene>
+
The line below this paragraph, containing "STRUCTURE_1jm4", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1jm4| PDB=1jm4 | SCENE= }}
-
|RELATEDENTRY=[[1b91|1B91]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jm4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jm4 OCA], [http://www.ebi.ac.uk/pdbsum/1jm4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jm4 RCSB]</span>
+
-
}}
+
'''NMR Structure of P/CAF Bromodomain in Complex with HIV-1 Tat Peptide'''
'''NMR Structure of P/CAF Bromodomain in Complex with HIV-1 Tat Peptide'''
Line 33: Line 30:
[[Category: Zeng, L.]]
[[Category: Zeng, L.]]
[[Category: Zhou, M M.]]
[[Category: Zhou, M M.]]
-
[[Category: bromodomain]]
+
[[Category: Bromodomain]]
-
[[Category: protein-peptide complex]]
+
[[Category: Protein-peptide complex]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:23:44 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:35:38 2008''
+

Revision as of 18:23, 2 May 2008

Image:1jm4.gif

Template:STRUCTURE 1jm4

NMR Structure of P/CAF Bromodomain in Complex with HIV-1 Tat Peptide


Overview

The human immunodeficiency virus type 1 (HIV-1) trans-activator protein Tat stimulates transcription of the integrated HIV-1 genome and promotes viral replication in infected cells. Tat transactivation activity is dependent on lysine acetylation and its association with nuclear histone acetyltransferases p300/CBP (CREB binding protein) and p300/CBP-associated factor (PCAF). Here, we show that the bromodomain of PCAF binds specifically to HIV-1 Tat acetylated at lysine 50 and that this interaction competes effectively against HIV-1 TAR RNA binding to the lysine-acetylated Tat. The three-dimensional solution structure of the PCAF bromodomain in complex with a lysine 50-acetylated Tat peptide together with biochemical analyses provides the structural basis for the specificity of this molecular recognition and reveals insights into the differences in ligand selectivity of bromodomains.

About this Structure

1JM4 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain., Mujtaba S, He Y, Zeng L, Farooq A, Carlson JE, Ott M, Verdin E, Zhou MM, Mol Cell. 2002 Mar;9(3):575-86. PMID:11931765 Page seeded by OCA on Fri May 2 21:23:44 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1jm4"
Personal tools