1jm7

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[[Image:1jm7.gif|left|200px]]
[[Image:1jm7.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1jm7 |SIZE=350|CAPTION= <scene name='initialview01'>1jm7</scene>
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The line below this paragraph, containing "STRUCTURE_1jm7", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE= BRCA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), BARD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_1jm7| PDB=1jm7 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jm7 OCA], [http://www.ebi.ac.uk/pdbsum/1jm7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jm7 RCSB]</span>
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'''Solution structure of the BRCA1/BARD1 RING-domain heterodimer'''
'''Solution structure of the BRCA1/BARD1 RING-domain heterodimer'''
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[[Category: Klevit, R E.]]
[[Category: Klevit, R E.]]
[[Category: Rajagopal, P.]]
[[Category: Rajagopal, P.]]
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[[Category: bard1]]
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[[Category: Bard1]]
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[[Category: brca1]]
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[[Category: Brca1]]
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[[Category: heterodimer]]
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[[Category: Heterodimer]]
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[[Category: ring finger]]
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[[Category: Ring finger]]
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[[Category: ubiquitin ligase]]
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[[Category: Ubiquitin ligase]]
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[[Category: zinc-binding protein]]
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[[Category: Zinc-binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:23:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:35:40 2008''
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Revision as of 18:23, 2 May 2008

Image:1jm7.gif

Template:STRUCTURE 1jm7

Solution structure of the BRCA1/BARD1 RING-domain heterodimer


Contents

Overview

The RING domain of the breast and ovarian cancer tumor suppressor BRCA1 interacts with multiple cognate proteins, including the RING protein BARD1. Proper function of the BRCA1 RING domain is critical, as evidenced by the many cancer-predisposing mutations found within this domain. We present the solution structure of the heterodimer formed between the RING domains of BRCA1 and BARD1. Comparison with the RING homodimer of the V(D)J recombination-activating protein RAG1 reveals the structural diversity of complexes formed by interactions between different RING domains. The BRCA1-BARD1 structure provides a model for its ubiquitin ligase activity, illustrates how the BRCA1 RING domain can be involved in associations with multiple protein partners and provides a framework for understanding cancer-causing mutations at the molecular level.

Disease

Known disease associated with this structure: Breast cancer-1 OMIM:[113705], Breast-ovarian cancer OMIM:[113705], Ovarian cancer OMIM:[113705], Papillary serous carcinoma of the peritoneum OMIM:[113705], Breast cancer, susceptibility to OMIM:[601593]

About this Structure

1JM7 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of a BRCA1-BARD1 heterodimeric RING-RING complex., Brzovic PS, Rajagopal P, Hoyt DW, King MC, Klevit RE, Nat Struct Biol. 2001 Oct;8(10):833-7. PMID:11573085 Page seeded by OCA on Fri May 2 21:23:49 2008

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