7pqh
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of Saccharomyces cerevisiae TOROID (TORC1 Organized in Inhibited Domains).== | |
| - | + | <StructureSection load='7pqh' size='340' side='right'caption='[[7pqh]], [[Resolution|resolution]] 3.87Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7pqh]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PQH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PQH FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pqh OCA], [https://pdbe.org/7pqh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pqh RCSB], [https://www.ebi.ac.uk/pdbsum/7pqh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pqh ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/KOG1_YEAST KOG1_YEAST] Component of TORC1, which regulates multiple cellular processes to control cell growth in response to environmental signals. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls ribosome biogenesis via control of rRNA, ribosomal protein and tRNA gene expression, and rRNA processing. TORC1 positively controls protein biosynthesis by regulation of mRNA stability, translation initiation factor activity, and high-affinity amino acid permeases that serve to provide amino acids for use by the translation machinery. TORC1 also promotes growth by sequestering a number of nutrient and general stress-responsive transcription factors in the cytoplasm. TORC1 negatively controls macroautophagy, a process to recycle surplus cytoplasmic mass under nutrient starvation conditions. KOG1 may have a role in binding and recruiting substrates of TORC1.<ref>PMID:16394584</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Saccharomyces cerevisiae]] |
| - | [[Category: | + | [[Category: Bonadei L]] |
| - | [[Category: | + | [[Category: Bourgoint C]] |
| + | [[Category: Desfosses A]] | ||
| + | [[Category: Felix J]] | ||
| + | [[Category: Gabus C]] | ||
| + | [[Category: Gutsche I]] | ||
| + | [[Category: Loewith R]] | ||
| + | [[Category: Prouteau M]] | ||
| + | [[Category: Sadian Y]] | ||
| + | [[Category: Savvides SN]] | ||
Revision as of 07:10, 18 January 2023
Cryo-EM structure of Saccharomyces cerevisiae TOROID (TORC1 Organized in Inhibited Domains).
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