7xc5

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'''Unreleased structure'''
 
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The entry 7xc5 is ON HOLD until Paper Publication
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==Crystal structure of the ANK domain of CLPB==
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<StructureSection load='7xc5' size='340' side='right'caption='[[7xc5]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7xc5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XC5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XC5 FirstGlance]. <br>
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Description:
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xc5 OCA], [https://pdbe.org/7xc5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xc5 RCSB], [https://www.ebi.ac.uk/pdbsum/7xc5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xc5 ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CLPB_HUMAN CLPB_HUMAN] 3-methylglutaconic aciduria type 7;Autosomal dominant severe congenital neutropenia. The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/CLPB_HUMAN CLPB_HUMAN] May function as a regulatory ATPase and be related to secretion/protein trafficking process. Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 (PubMed:31522117).<ref>PMID:31522117</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Gao N]]
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[[Category: Lin J]]
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[[Category: Liu Y]]
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[[Category: Lu G]]
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[[Category: Wu D]]

Revision as of 07:20, 18 January 2023

Crystal structure of the ANK domain of CLPB

PDB ID 7xc5

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OCA

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