8a00

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Current revision (07:26, 18 January 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8a00 is ON HOLD until Paper Publication
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==Infectious mouse-adapted ME7 scrapie prion fibril purified from terminally-infected mouse brains==
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<StructureSection load='8a00' size='340' side='right'caption='[[8a00]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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Authors: Manka, S.W., Wenborn, A., Betts, J., Joiner, S., Saibil, H.R., Collinge, J., Wadsworth, J.D.F.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8a00]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8A00 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8A00 FirstGlance]. <br>
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Description: Infectious mouse-adapted ME7 scrapie prion fibril purified from terminally-infected mouse brains
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a00 OCA], [https://pdbe.org/8a00 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a00 RCSB], [https://www.ebi.ac.uk/pdbsum/8a00 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a00 ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Wenborn, A]]
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== Disease ==
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[[Category: Collinge, J]]
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[https://www.uniprot.org/uniprot/PRIO_MOUSE PRIO_MOUSE] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
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[[Category: Wadsworth, J.D.F]]
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== Function ==
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[[Category: Betts, J]]
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[https://www.uniprot.org/uniprot/PRIO_MOUSE PRIO_MOUSE] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains.<ref>PMID:12732622</ref> <ref>PMID:16492732</ref> <ref>PMID:19242475</ref> <ref>PMID:19568430</ref>
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[[Category: Manka, S.W]]
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== References ==
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[[Category: Saibil, H.R]]
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<references/>
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[[Category: Joiner, S]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Betts J]]
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[[Category: Collinge J]]
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[[Category: Joiner S]]
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[[Category: Manka SW]]
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[[Category: Saibil HR]]
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[[Category: Wadsworth JDF]]
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[[Category: Wenborn A]]

Current revision

Infectious mouse-adapted ME7 scrapie prion fibril purified from terminally-infected mouse brains

PDB ID 8a00

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