8f0w

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m (Protected "8f0w" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 8f0w is ON HOLD
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==Tudor Domain of Tumor suppressor p53BP1 with MFP-5956==
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<StructureSection load='8f0w' size='340' side='right'caption='[[8f0w]], [[Resolution|resolution]] 1.52&Aring;' scene=''>
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Authors: The, J., Hong, Z., Dong, A., Headey, S., Gunzburg, M., Doak, B., James, L.I., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8f0w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8F0W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8F0W FirstGlance]. <br>
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Description: Tudor Domain of Tumor suppressor p53BP1 with MFP-5956
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=X9N:1-[4-(4-ethylpiperazin-1-yl)-3-fluorophenyl]butan-1-one'>X9N</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8f0w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8f0w OCA], [https://pdbe.org/8f0w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8f0w RCSB], [https://www.ebi.ac.uk/pdbsum/8f0w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8f0w ProSAT]</span></td></tr>
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[[Category: Gunzburg, M]]
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</table>
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[[Category: James, L.I]]
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== Disease ==
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[[Category: Edwards, A.M]]
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[https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein.
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[[Category: Headey, S]]
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== Function ==
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[[Category: Arrowsmith, C.H]]
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[https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref> <ref>PMID:17190600</ref>
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[[Category: Dong, A]]
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== References ==
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[[Category: Hong, Z]]
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<references/>
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[[Category: The, J]]
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__TOC__
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[[Category: Structural Genomics Consortium (Sgc)]]
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</StructureSection>
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[[Category: Brown, P.J]]
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[[Category: Homo sapiens]]
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[[Category: Doak, B]]
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[[Category: Large Structures]]
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[[Category: Bountra, C]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra C]]
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[[Category: Brown PJ]]
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[[Category: Doak B]]
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[[Category: Dong A]]
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[[Category: Edwards AM]]
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[[Category: Gunzburg M]]
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[[Category: Headey S]]
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[[Category: Hong Z]]
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[[Category: James LI]]
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[[Category: The J]]

Revision as of 07:33, 18 January 2023

Tudor Domain of Tumor suppressor p53BP1 with MFP-5956

PDB ID 8f0w

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OCA

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