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8fbh
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of NSD1 Mutant-T1927A== | |
| - | + | <StructureSection load='8fbh' size='340' side='right'caption='[[8fbh]], [[Resolution|resolution]] 2.32Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8fbh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FBH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FBH FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fbh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fbh OCA], [https://pdbe.org/8fbh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fbh RCSB], [https://www.ebi.ac.uk/pdbsum/8fbh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fbh ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/NSD1_MOUSE NSD1_MOUSE] Histone methyltransferase. Preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4 (in vitro). Transcriptional intermediary factor capable of negatively influencing transcription. May also positively influence transcription. Essential for early post-implantation development.<ref>PMID:12805229</ref> <ref>PMID:9628876</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: Providokhina | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Arrowsmith CH]] | ||
| + | [[Category: Dong A]] | ||
| + | [[Category: Edwards AM]] | ||
| + | [[Category: Min J]] | ||
| + | [[Category: Providokhina K]] | ||
Revision as of 07:34, 18 January 2023
Crystal structure of NSD1 Mutant-T1927A
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