8hub
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The entry | + | ==AMP deaminase 2 in complex with an inhibitor== |
| - | + | <StructureSection load='8hub' size='340' side='right'caption='[[8hub]], [[Resolution|resolution]] 3.25Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8hub]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HUB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HUB FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=N4X:3,3-dimethyl-4-(phenylmethyl)-2~{H}-quinoxaline-1-carboxamide'>N4X</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hub OCA], [https://pdbe.org/8hub PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hub RCSB], [https://www.ebi.ac.uk/pdbsum/8hub PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hub ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/AMPD2_HUMAN AMPD2_HUMAN] Autosomal recessive spastic paraplegia type 63;Pontocerebellar hypoplasia type 9. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/AMPD2_HUMAN AMPD2_HUMAN] AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle.<ref>PMID:23911318</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Adachi T]] | ||
| + | [[Category: Doi S]] | ||
Revision as of 07:36, 18 January 2023
AMP deaminase 2 in complex with an inhibitor
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