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| | ==NMR Structure of hFn14== | | ==NMR Structure of hFn14== |
| - | <StructureSection load='2kmz' size='340' side='right'caption='[[2kmz]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2kmz' size='340' side='right'caption='[[2kmz]]' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[2kmz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KMZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KMZ FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[2kmz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KMZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KMZ FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FN14, TNFRSF12A ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kmz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kmz OCA], [https://pdbe.org/2kmz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kmz RCSB], [https://www.ebi.ac.uk/pdbsum/2kmz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kmz ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kmz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kmz OCA], [https://pdbe.org/2kmz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kmz RCSB], [https://www.ebi.ac.uk/pdbsum/2kmz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kmz ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[https://www.uniprot.org/uniprot/TNR12_HUMAN TNR12_HUMAN]] Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.<ref>PMID:11728344</ref>
| + | [https://www.uniprot.org/uniprot/TNR12_HUMAN TNR12_HUMAN] Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.<ref>PMID:11728344</ref> |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Human]] | + | [[Category: Homo sapiens]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Cuervo, H]] | + | [[Category: Cuervo H]] |
| - | [[Category: Day, E S]] | + | [[Category: Day ES]] |
| - | [[Category: Krushinskie, D]] | + | [[Category: Krushinskie D]] |
| - | [[Category: Pellegrini, M]] | + | [[Category: Pellegrini M]] |
| - | [[Category: Perroud, M]] | + | [[Category: Perroud M]] |
| - | [[Category: Schneider, P]] | + | [[Category: Schneider P]] |
| - | [[Category: Strauch, K]] | + | [[Category: Strauch K]] |
| - | [[Category: Sun, Y]] | + | [[Category: Sun Y]] |
| - | [[Category: Willen, L]] | + | [[Category: Willen L]] |
| - | [[Category: Zheng, T S]] | + | [[Category: Zheng TS]] |
| - | [[Category: Angiogenesis]]
| + | |
| - | [[Category: Apoptosis]]
| + | |
| - | [[Category: Cell adhesion]]
| + | |
| - | [[Category: Crd]]
| + | |
| - | [[Category: Developmental protein]]
| + | |
| - | [[Category: Differentiation]]
| + | |
| - | [[Category: Disulfide bond]]
| + | |
| - | [[Category: Fn14]]
| + | |
| - | [[Category: Membrane]]
| + | |
| - | [[Category: Receptor]]
| + | |
| - | [[Category: Tnf receptor]]
| + | |
| - | [[Category: Tnfrsf12a]]
| + | |
| - | [[Category: Transmembrane]]
| + | |
| - | [[Category: Tweak]]
| + | |
| Structural highlights
Function
TNR12_HUMAN Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.[1]
Publication Abstract from PubMed
TWEAK (TNF homologue with weak apoptosis-inducing activity) and Fn14 (fibroblast growth factor-inducible protein 14) are members of the tumor necrosis factor (TNF) ligand and receptor super-families. Having observed that Xenopus Fn14 cross-reacts with human TWEAK, despite its relatively low sequence homology to human Fn14, we examined the conservation in tertiary fold and binding interfaces between the two species. Our results, combining NMR solution structure determination, binding assays, extensive site-directed mutagenesis and molecular modeling, reveal that, in addition to the known and previously characterized beta-hairpin motif, the helix-loop-helix motif makes an essential contribution to the receptor/ligand binding interface. We further discuss the insight provided by the structural analyses regarding how the cysteine-rich domains of the TNF receptor super-family may have evolved over time. DATABASE: Structural data are available in the Protein Data Bank/BioMagResBank databases under the accession codes 2KMZ, 2KN0 and 2KN1 and 17237, 17247 and 17252. STRUCTURED DIGITAL ABSTRACT: TWEAK binds to hFn14 by surface plasmon resonance (View interaction) xeFn14 binds to TWEAK by enzyme linked immunosorbent assay (View interaction) TWEAK binds to xeFn14 by surface plasmon resonance (View interaction) hFn14 binds to TWEAK by enzyme linked immunosorbent assay (View interaction).
Structure of the extracellular domains of human and Xenopus Fn14: implications in the evolution of TWEAK and Fn14 interactions.,Pellegrini M, Willen L, Perroud M, Krushinskie D, Strauch K, Cuervo H, Day ES, Schneider P, Zheng TS FEBS J. 2013 Feb 25. doi: 10.1111/febs.12206. PMID:23438059[2]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Wiley SR, Cassiano L, Lofton T, Davis-Smith T, Winkles JA, Lindner V, Liu H, Daniel TO, Smith CA, Fanslow WC. A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis. Immunity. 2001 Nov;15(5):837-46. PMID:11728344
- ↑ Pellegrini M, Willen L, Perroud M, Krushinskie D, Strauch K, Cuervo H, Day ES, Schneider P, Zheng TS. Structure of the extracellular domains of human and Xenopus Fn14: implications in the evolution of TWEAK and Fn14 interactions. FEBS J. 2013 Feb 25. doi: 10.1111/febs.12206. PMID:23438059 doi:http://dx.doi.org/10.1111/febs.12206
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