1jn9

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[[Image:1jn9.jpg|left|200px]]
[[Image:1jn9.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1jn9 |SIZE=350|CAPTION= <scene name='initialview01'>1jn9</scene>, resolution 2.3&Aring;
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The line below this paragraph, containing "STRUCTURE_1jn9", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Na+Binding+Site+For+Residue+A+401'>AC1</scene>, <scene name='pdbsite=AC2:Na+Binding+Site+For+Residue+C+402'>AC2</scene>, <scene name='pdbsite=AC3:Cl+Binding+Site+For+Residue+A+403'>AC3</scene>, <scene name='pdbsite=AC4:Cl+Binding+Site+For+Residue+D+404'>AC4</scene>, <scene name='pdbsite=AC5:Cl+Binding+Site+For+Residue+C+405'>AC5</scene>, <scene name='pdbsite=AC6:Cl+Binding+Site+For+Residue+D+406'>AC6</scene>, <scene name='pdbsite=AC7:Ca+Binding+Site+For+Residue+A+407'>AC7</scene>, <scene name='pdbsite=AC8:Ca+Binding+Site+For+Residue+A+408'>AC8</scene> and <scene name='pdbsite=AC9:Ca+Binding+Site+For+Residue+B+409'>AC9</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Asparaginase Asparaginase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.1 3.5.1.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04701 Asparaginase_2]</span>
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{{STRUCTURE_1jn9| PDB=1jn9 | SCENE= }}
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|RELATEDENTRY=[[1apy|1APY]], [[1apz|1APZ]], [[1ayy|1AYY]], [[2gac|2GAC]], [[2gaw|2GAW]], [[9gaa|9GAA]], [[9gac|9GAC]], [[9gaf|9GAF]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jn9 OCA], [http://www.ebi.ac.uk/pdbsum/1jn9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jn9 RCSB]</span>
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}}
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'''Structure of Putative Asparaginase Encoded by Escherichia coli ybiK Gene'''
'''Structure of Putative Asparaginase Encoded by Escherichia coli ybiK Gene'''
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[[Category: Borek, D.]]
[[Category: Borek, D.]]
[[Category: Jaskolski, M.]]
[[Category: Jaskolski, M.]]
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[[Category: asparaginase]]
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[[Category: Asparaginase]]
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[[Category: autoproteolysis]]
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[[Category: Autoproteolysis]]
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[[Category: ntn hydrolase]]
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[[Category: Ntn hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:26:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 2 11:31:25 2008''
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Revision as of 18:26, 2 May 2008

Image:1jn9.jpg

Template:STRUCTURE 1jn9

Structure of Putative Asparaginase Encoded by Escherichia coli ybiK Gene


Overview

Plant-type L-asparaginases hydrolyze the side-chain amide bond of L-asparagine or its beta-peptides. They belong to the N-terminal nucleophile (Ntn) hydrolases and are synthesized as inactive precursor molecules. Activation occurs via the autoproteolytic release of two subunits, alpha and beta, the latter of which carries the nucleophile at its N-terminus. Crystallographic studies of plant-type asparaginases have focused on an Escherichia coli homologue (EcAIII), which has been crystallized in several crystal forms. Although they all belong to the same P2(1)2(1)2(1) space group with similar unit-cell parameters, they display different crystal-packing arrangements and thus should be classified as separate polymorphs. This variability stems mainly from different positions of the EcAIII molecules within the unit cell, although they also exhibit slight differences in orientation. The intermolecular interactions that trigger different crystal lattice formation are mediated by ions, which represent the most variable component of the crystallization conditions. This behaviour confirms recent observations that small molecules might promote protein crystal lattice formation.

About this Structure

1JN9 is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal packing of plant-type L-asparaginase from Escherichia coli., Michalska K, Borek D, Hernandez-Santoyo A, Jaskolski M, Acta Crystallogr D Biol Crystallogr. 2008 Mar;64(Pt 3):309-20. Epub 2008, Feb 20. PMID:18323626 Page seeded by OCA on Fri May 2 21:26:48 2008

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