2l9r
From Proteopedia
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==Solution NMR Structure of Homeobox domain of Homeobox protein Nkx-3.1 from homo sapiens, Northeast Structural Genomics Consortium Target HR6470A== | ==Solution NMR Structure of Homeobox domain of Homeobox protein Nkx-3.1 from homo sapiens, Northeast Structural Genomics Consortium Target HR6470A== | ||
| - | <StructureSection load='2l9r' size='340' side='right'caption='[[2l9r | + | <StructureSection load='2l9r' size='340' side='right'caption='[[2l9r]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2l9r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2l9r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L9R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L9R FirstGlance]. <br> |
| - | </td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l9r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l9r OCA], [https://pdbe.org/2l9r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l9r RCSB], [https://www.ebi.ac.uk/pdbsum/2l9r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l9r ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l9r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l9r OCA], [https://pdbe.org/2l9r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l9r RCSB], [https://www.ebi.ac.uk/pdbsum/2l9r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l9r ProSAT]</span></td></tr> | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/NKX31_HUMAN NKX31_HUMAN] Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.<ref>PMID:19462257</ref> | |
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| + | ==See Also== | ||
| + | *[[NKX2.5 Homeodomain|NKX2.5 Homeodomain]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Acton | + | [[Category: Acton TB]] |
| - | [[Category: Ciccosanti | + | [[Category: Ciccosanti C]] |
| - | [[Category: Everett | + | [[Category: Everett JK]] |
| - | [[Category: Hamilton | + | [[Category: Hamilton K]] |
| - | [[Category: Huang | + | [[Category: Huang YJ]] |
| - | [[Category: Lee | + | [[Category: Lee H-W]] |
| - | [[Category: Liu | + | [[Category: Liu G]] |
| - | [[Category: Montelione | + | [[Category: Montelione GT]] |
| - | + | [[Category: Wang HB]] | |
| - | [[Category: Wang | + | [[Category: Xiao R]] |
| - | [[Category: Xiao | + | |
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Revision as of 08:27, 18 January 2023
Solution NMR Structure of Homeobox domain of Homeobox protein Nkx-3.1 from homo sapiens, Northeast Structural Genomics Consortium Target HR6470A
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Categories: Homo sapiens | Large Structures | Acton TB | Ciccosanti C | Everett JK | Hamilton K | Huang YJ | Lee H-W | Liu G | Montelione GT | Wang HB | Xiao R
