1jnq

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[[Image:1jnq.jpg|left|200px]]
[[Image:1jnq.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1jnq |SIZE=350|CAPTION= <scene name='initialview01'>1jnq</scene>, resolution 2.1&Aring;
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The line below this paragraph, containing "STRUCTURE_1jnq", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=FE:Fe+(Fe+2)+Active+Site'>FE</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=EGT:2-(3,4,5-TRIHYDROXY-PHENYL)-CHROMAN-3,5,7-TRIOL'>EGT</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Lipoxygenase Lipoxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.12 1.13.11.12] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1jnq| PDB=1jnq | SCENE= }}
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|RELATEDENTRY=[[1byt|1BYT]], [[1lnh|1LNH]], [[1f8n|1F8N]], [[1lox|1LOX]], [[1ik3|1IK3]], [[1hu9|1HU9]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jnq OCA], [http://www.ebi.ac.uk/pdbsum/1jnq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jnq RCSB]</span>
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}}
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'''LIPOXYGENASE-3 (SOYBEAN) COMPLEX WITH EPIGALLOCATHECHIN (EGC)'''
'''LIPOXYGENASE-3 (SOYBEAN) COMPLEX WITH EPIGALLOCATHECHIN (EGC)'''
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[[Category: Skrzypczak-Jankun, E.]]
[[Category: Skrzypczak-Jankun, E.]]
[[Category: Zhou, K.]]
[[Category: Zhou, K.]]
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[[Category: catechin inhibitor]]
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[[Category: Catechin inhibitor]]
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[[Category: fe(ii) complex]]
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[[Category: Green tea]]
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[[Category: green tea]]
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[[Category: Metalloprotein]]
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[[Category: metalloprotein]]
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[[Category: Purple lipoxygenase]]
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[[Category: purple lipoxygenase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:28:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:36:20 2008''
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Revision as of 18:28, 2 May 2008

Image:1jnq.jpg

Template:STRUCTURE 1jnq

LIPOXYGENASE-3 (SOYBEAN) COMPLEX WITH EPIGALLOCATHECHIN (EGC)


Overview

Lipoxygenases (LOXs) are non-heme iron containing enzymes ubiquitous in nature and participating in the metabolism of the polyunsaturated fatty acids (PUFA). They are capable of combining their dioxygenase activity with its co-oxidative activity manifesting itself in biotransformation reactions catalyzed by LOXs for other than PUFA small molecules. LOXs involvement in inflammatory diseases and cancer have been well documented. Catechins are the natural flavonoids of known inhibitory activity toward dioxygenases with a potential to be utilized in disease prevention and treatment. This work presents results obtained from an X-ray analysis of (-)-epigallocatechin gallate (EGCG) interacting with soybean lipoxygenase-3. The 3D structure of the resulting complex reveals the inhibitor depicting (-)-epigallo-catechin that lacks galloyl moiety. The A-ring is near the iron co-factor, attached by the hydrogen bond to the C-terminus of the enzyme, and the B-ring hydroxyl groups participate in the hydrogen bonds and the van der Waals interactions formed by the surrounding amino acids and water molecules.

About this Structure

1JNQ is a Single protein structure of sequence from Glycine max. Full crystallographic information is available from OCA.

Reference

Inhibition of lipoxygenase by (-)-epigallocatechin gallate: X-ray analysis at 2.1 A reveals degradation of EGCG and shows soybean LOX-3 complex with EGC instead., Skrzypczak-Jankun E, Zhou K, Jankun J, Int J Mol Med. 2003 Oct;12(4):415-20. PMID:12964012 Page seeded by OCA on Fri May 2 21:28:01 2008

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