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4nzh
From Proteopedia
(Difference between revisions)
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<StructureSection load='4nzh' size='340' side='right'caption='[[4nzh]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='4nzh' size='340' side='right'caption='[[4nzh]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4nzh]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4nzh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NZH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NZH FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nzh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nzh OCA], [https://pdbe.org/4nzh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nzh RCSB], [https://www.ebi.ac.uk/pdbsum/4nzh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nzh ProSAT]</span></td></tr> | |
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SIDA_ASPFU SIDA_ASPFU] Catalyzes the conversion of L-ornithine to N(5)-hydroxyornithine, the first step in the biosynthesis of all hydroxamate-containing siderophores, such as the secreted triacetylfusarinine C (TAFC) involved in iron uptake and the intracellular iron storage compound desferriferricrocin (DFFC). Highly specific for its substrate, only hydrolyzing l-ornithine. Has preference for NADPH over NADH, NADPH playing a role in stabilization of the C4a-hydroperoxyflavin intermediate. Essential for virulence.<ref>PMID:15504822</ref> <ref>PMID:16113265</ref> <ref>PMID:20614882</ref> <ref>PMID:22465572</ref> | ||
==See Also== | ==See Also== | ||
| - | *[[Monooxygenase|Monooxygenase]] | + | *[[Monooxygenase 3D structures|Monooxygenase 3D structures]] |
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Aspergillus fumigatus]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Franceschini | + | [[Category: Franceschini S]] |
| - | [[Category: Robinson | + | [[Category: Robinson R]] |
| - | [[Category: Sobrado | + | [[Category: Sobrado P]] |
| - | + | ||
Revision as of 08:47, 18 January 2023
A. fumigatus flavin-dependent ornithine monooxygenase R279A mutant
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