4o6l
From Proteopedia
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<StructureSection load='4o6l' size='340' side='right'caption='[[4o6l]], [[Resolution|resolution]] 2.38Å' scene=''> | <StructureSection load='4o6l' size='340' side='right'caption='[[4o6l]], [[Resolution|resolution]] 2.38Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4o6l]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4o6l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O6L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O6L FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2QK:N-[(1R)-1-(2-CHLOROPHENYL)PROPYL]-3-{4-[(1-METHYLPIPERIDIN-4-YL)OXY]PHENYL}-1H-INDAZOLE-5-CARBOXAMIDE'>2QK</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2QK:N-[(1R)-1-(2-CHLOROPHENYL)PROPYL]-3-{4-[(1-METHYLPIPERIDIN-4-YL)OXY]PHENYL}-1H-INDAZOLE-5-CARBOXAMIDE'>2QK</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o6l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o6l OCA], [https://pdbe.org/4o6l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o6l RCSB], [https://www.ebi.ac.uk/pdbsum/4o6l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o6l ProSAT]</span></td></tr> | |
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref> |
==See Also== | ==See Also== | ||
| - | *[[Dual specificity protein kinase|Dual specificity protein kinase]] | + | *[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
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[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Awrey | + | [[Category: Awrey DE]] |
| - | [[Category: Chirgadze | + | [[Category: Chirgadze NY]] |
| - | [[Category: Feher | + | [[Category: Feher M]] |
| - | [[Category: Plotnikova | + | [[Category: Plotnikova O]] |
| - | [[Category: Qiu | + | [[Category: Qiu W]] |
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Revision as of 08:58, 18 January 2023
Crystal Structure of TTK kinase domain with an inhibitor: 401498 (N-[(1R)-1-(2-chlorophenyl)propyl]-3-{4-[(1-methylpiperidin-4-yl)oxy]phenyl}-1H-indazole-5-carboxamide)
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