1joc
From Proteopedia
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[[Image:1joc.gif|left|200px]] | [[Image:1joc.gif|left|200px]] | ||
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'''EEA1 homodimer of C-terminal FYVE domain bound to inositol 1,3-diphosphate''' | '''EEA1 homodimer of C-terminal FYVE domain bound to inositol 1,3-diphosphate''' | ||
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[[Category: Merithew, E.]] | [[Category: Merithew, E.]] | ||
[[Category: Rajamani, D.]] | [[Category: Rajamani, D.]] | ||
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| - | [[Category: | + | [[Category: Inositol 3-phosphate binding]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:30:00 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 18:30, 2 May 2008
EEA1 homodimer of C-terminal FYVE domain bound to inositol 1,3-diphosphate
Overview
Early endosome autoantigen localization to early endosomes is mediated by a C-terminal region, which includes a calmodulin binding motif, a Rab5 interaction site, and a FYVE domain that selectively binds phosphatidyl inositol 3-phosphate. The crystal structure of the C-terminal region bound to inositol 1,3-bisphosphate reveals an organized, quaternary assembly consisting of a parallel coiled coil and a dyad-symmetric FYVE domain homodimer. Structural and biochemical observations support a multivalent mechanism for endosomal localization in which domain organization, dimerization, and quaternary structure amplify the weak affinity and modest specificity of head group interactions with conserved residues. A unique mode of membrane engagement deduced from the quaternary structure of the C-terminal region provides insight into the structural basis of endosome tethering.
About this Structure
1JOC is a Single protein structure of sequence from Homo sapiens. The following page contains interesting information on the relation of 1JOC with [Zinc Fingers]. Full crystallographic information is available from OCA.
Reference
Multivalent endosome targeting by homodimeric EEA1., Dumas JJ, Merithew E, Sudharshan E, Rajamani D, Hayes S, Lawe D, Corvera S, Lambright DG, Mol Cell. 2001 Nov;8(5):947-58. PMID:11741531 Page seeded by OCA on Fri May 2 21:30:00 2008
