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7pna

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'''Unreleased structure'''
 
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The entry 7pna is ON HOLD until Paper Publication
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==Evolved unspecific peroxygenase with A77L mutation in complex with 12-methoxylauric acid==
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<StructureSection load='7pna' size='340' side='right'caption='[[7pna]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7pna]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cyclocybe_aegerita Cyclocybe aegerita]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PNA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PNA FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7UT:12-methoxylauric+acid'>7UT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pna FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pna OCA], [https://pdbe.org/7pna PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pna RCSB], [https://www.ebi.ac.uk/pdbsum/7pna PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pna ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/APO1_CYCAE APO1_CYCAE] Aromatic peroxidase that oxidizes aryl alcohols into the corresponding aldehydes and then into the corresponding benzoic acids. Oxidizes toluene and naphthalene. Catalyzes the regioselective peroxide-dependent hydroxylation of propranolol and diclofenac to 5-hydroxypropranolol and 4'-hydroxydiclofenac. Catalyzes the regioselective peroxide-dependent hydroxylation of naphthalene to 1-naphthol or 2-naphthol via a naphthalene 1,2-oxide intermediate. Catalyzes the regioselective peroxide-dependent oxidation of pyridine to pyridine N-oxide. Halogenates monochlorodimedone and phenol. Oxidizes the sulfur-containing heterocycle dibenzothiophene to yield ring-hydroxylation products and to a lesser extent sulfoxidation products.<ref>PMID:15294788</ref> <ref>PMID:16253244</ref> <ref>PMID:17410351</ref> <ref>PMID:18815784</ref> <ref>PMID:19022254</ref> <ref>PMID:19039585</ref> <ref>PMID:19394224</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Cyclocybe aegerita]]
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[[Category: Large Structures]]
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[[Category: Fernandez-Garcia A]]
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[[Category: Sanz-Aparicio J]]

Revision as of 06:26, 25 January 2023

Evolved unspecific peroxygenase with A77L mutation in complex with 12-methoxylauric acid

PDB ID 7pna

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