7tmc

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'''Unreleased structure'''
 
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The entry 7tmc is ON HOLD until Paper Publication
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==TMEM106B singlet filament extracted from MSTD neurodegenerative human brain==
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<StructureSection load='7tmc' size='340' side='right'caption='[[7tmc]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
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Authors: Hoq, M.R., Bharath, S.R., Jiang, W.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7tmc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TMC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TMC FirstGlance]. <br>
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Description: TMEM106B singlet filament extracted from MSTD neurodegenerative human brain
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tmc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tmc OCA], [https://pdbe.org/7tmc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tmc RCSB], [https://www.ebi.ac.uk/pdbsum/7tmc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tmc ProSAT]</span></td></tr>
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[[Category: Jiang, W]]
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</table>
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[[Category: Hoq, M.R]]
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== Disease ==
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[[Category: Bharath, S.R]]
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[https://www.uniprot.org/uniprot/T106B_HUMAN T106B_HUMAN] Progressive non-fluent aphasia;Semantic dementia;Behavioral variant of frontotemporal dementia. The gene represented in this entry acts as a disease modifier. Risk alleles confer genetic susceptibility by increasing gene expression (PubMed:20154673, PubMed:21178100). Increased expression may be the result of down-regulation of microRNA miR-132 and miR-212, that repress TMEM106B expression (PubMed:22895706). Thr-185 is a risk allele associated with lower GRN protein levels and early age at onset in GRN UP-FTD mutation carriers: it presents slower protein degradation that leads to higher steady-state TMEM106B levels, leading to alterations in the intracellular versus extracellular partitioning of GRN (PubMed:23742080).<ref>PMID:20154673</ref> <ref>PMID:21178100</ref> <ref>PMID:22895706</ref> <ref>PMID:23742080</ref> The gene represented in this entry acts as a disease modifier. The disease may be caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/T106B_HUMAN T106B_HUMAN] Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with MAP6. May act by inhibiting retrograde transport of lysosomes along dendrites. Required for dendrite branching.<ref>PMID:23136129</ref> <ref>PMID:24357581</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Bharath SR]]
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[[Category: Hoq MR]]
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[[Category: Jiang W]]

Revision as of 06:30, 25 January 2023

TMEM106B singlet filament extracted from MSTD neurodegenerative human brain

PDB ID 7tmc

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