7xbk

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Current revision (06:33, 25 January 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 7xbk is ON HOLD until Paper Publication
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==Structure and mechanism of a mitochondrial AAA+ disaggregase CLPB==
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<StructureSection load='7xbk' size='340' side='right'caption='[[7xbk]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7xbk]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XBK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XBK FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xbk OCA], [https://pdbe.org/7xbk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xbk RCSB], [https://www.ebi.ac.uk/pdbsum/7xbk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xbk ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CLPB_HUMAN CLPB_HUMAN] 3-methylglutaconic aciduria type 7;Autosomal dominant severe congenital neutropenia. The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/CLPB_HUMAN CLPB_HUMAN] May function as a regulatory ATPase and be related to secretion/protein trafficking process. Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 (PubMed:31522117).<ref>PMID:31522117</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Chen Y]]
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[[Category: Dai Y]]
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[[Category: Gao N]]
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[[Category: Li N]]
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[[Category: Lin J]]
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[[Category: Liu Y]]
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[[Category: Lu G]]
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[[Category: Wang G]]
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[[Category: Wu D]]

Current revision

Structure and mechanism of a mitochondrial AAA+ disaggregase CLPB

PDB ID 7xbk

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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