1jox
From Proteopedia
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[[Image:1jox.gif|left|200px]] | [[Image:1jox.gif|left|200px]] | ||
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'''NMR Structure of the LP5.1 Hairpin from Bacillus RNase P RNA Refined with Residual Dipolar Couplings''' | '''NMR Structure of the LP5.1 Hairpin from Bacillus RNase P RNA Refined with Residual Dipolar Couplings''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JOX OCA]. | |
==Reference== | ==Reference== | ||
Structure of the UGAGAU hexaloop that braces Bacillus RNase P for action., Leeper TC, Martin MB, Kim H, Cox S, Semenchenko V, Schmidt FJ, Van Doren SR, Nat Struct Biol. 2002 May;9(5):397-403. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11927952 11927952] | Structure of the UGAGAU hexaloop that braces Bacillus RNase P for action., Leeper TC, Martin MB, Kim H, Cox S, Semenchenko V, Schmidt FJ, Van Doren SR, Nat Struct Biol. 2002 May;9(5):397-403. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11927952 11927952] | ||
| - | [[Category: Protein complex]] | ||
[[Category: Doren, S R.Van.]] | [[Category: Doren, S R.Van.]] | ||
[[Category: Leeper, T C.]] | [[Category: Leeper, T C.]] | ||
[[Category: Schmidt, F J.]] | [[Category: Schmidt, F J.]] | ||
| - | [[Category: | + | [[Category: Hairpin]] |
| - | [[Category: | + | [[Category: Residual dipolar coupling refinement]] |
| - | [[Category: | + | [[Category: Ribonucleic acid]] |
| - | [[Category: | + | [[Category: Rnase p]] |
| - | [[Category: | + | [[Category: Ugnrau]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:31:58 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 18:31, 2 May 2008
NMR Structure of the LP5.1 Hairpin from Bacillus RNase P RNA Refined with Residual Dipolar Couplings
Overview
Long-range interactions involving the P5.1 hairpin of Bacillus RNase P RNA are thought to form a structural truss to support RNA folding and activity. We determined the structure of this element by NMR and refined the structure using residual dipolar couplings from a sample weakly oriented in a dilute liquid crystalline mixture of polyethylene glycol and hexanol. Dipolar coupling refinement improved the global precision of the structure from 1.5 to 1.2 A (to the mean), revised the bend angle between segments of the P5.1 stem and corroborated the structure of the loop region. The UGAGAU hexaloop of P5.1 contains two stacks of bases on opposite sides of the loop, distinguishing it from GNRA tetraloops. The unusual conformation of the juxtaposed uracil residues within the hexaloop may explain their requirement in transactivation assays.
About this Structure
Full crystallographic information is available from OCA.
Reference
Structure of the UGAGAU hexaloop that braces Bacillus RNase P for action., Leeper TC, Martin MB, Kim H, Cox S, Semenchenko V, Schmidt FJ, Van Doren SR, Nat Struct Biol. 2002 May;9(5):397-403. PMID:11927952 Page seeded by OCA on Fri May 2 21:31:58 2008
