1hkx

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<StructureSection load='1hkx' size='340' side='right'caption='[[1hkx]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
<StructureSection load='1hkx' size='340' side='right'caption='[[1hkx]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1hkx]] is a 14 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HKX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HKX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1hkx]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HKX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HKX FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=TBR:HEXATANTALUM+DODECABROMIDE'>TBR</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=TBR:HEXATANTALUM+DODECABROMIDE'>TBR</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1cdm|1cdm]]</div></td></tr>
 
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Calcium/calmodulin-dependent_protein_kinase Calcium/calmodulin-dependent protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.17 2.7.11.17] </span></td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hkx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hkx OCA], [https://pdbe.org/1hkx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hkx RCSB], [https://www.ebi.ac.uk/pdbsum/1hkx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hkx ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hkx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hkx OCA], [https://pdbe.org/1hkx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hkx RCSB], [https://www.ebi.ac.uk/pdbsum/1hkx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hkx ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KCC2A_MOUSE KCC2A_MOUSE] Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation (By similarity). Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (By similarity). Also regulates the migration of developing neurons (By similarity). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (PubMed:15994560). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway (By similarity). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (PubMed:23502535).[UniProtKB:P11275][UniProtKB:Q9UQM7]<ref>PMID:15994560</ref> <ref>PMID:23502535</ref> <ref>PMID:23805378</ref> Has no kinase activity.<ref>PMID:8524307</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Calcium/calmodulin-dependent protein kinase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Hoelz, A]]
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[[Category: Mus musculus]]
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[[Category: Kuriyan, J]]
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[[Category: Hoelz A]]
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[[Category: Nairn, A C]]
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[[Category: Kuriyan J]]
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[[Category: Alternative splicing]]
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[[Category: Nairn AC]]
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[[Category: Atp-binding]]
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[[Category: Calmodulin-binding]]
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[[Category: Phosphorylation]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: Transferase]]
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Revision as of 06:39, 25 January 2023

Crystal structure of calcium/calmodulin-dependent protein kinase

PDB ID 1hkx

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