1vj1
From Proteopedia
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<StructureSection load='1vj1' size='340' side='right'caption='[[1vj1]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='1vj1' size='340' side='right'caption='[[1vj1]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1vj1]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1vj1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VJ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VJ1 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vj1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vj1 OCA], [https://pdbe.org/1vj1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vj1 RCSB], [https://www.ebi.ac.uk/pdbsum/1vj1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vj1 ProSAT], [https://www.topsan.org/Proteins/JCSG/1vj1 TOPSAN]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/PTGR2_MOUSE PTGR2_MOUSE] Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.<ref>PMID:17449869</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Mus musculus]] |
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Revision as of 06:40, 25 January 2023
Crystal structure of putative NADPH-dependent oxidoreductase from Mus musculus at 2.10 A resolution
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